Suppression of testicular steroidogenesis in rats by the organochlorine insecticide Aldrin

Chatterjee, Satadal; Ray, Aritra; Bagchi, Preenon; Deb, Chandicharan

doi:10.1016/0269-7491(88)90198-4

Cited by 16 publications

(5 citation statements)

References 11 publications

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“…79 Administration of aldrin, an organochlorine insecticide, for 13 or 26 days, impaired steroidogenesis by suppressing the activities of 3b-HSD and 17b-HSD and through the release gonadotrophins from the pituitary. 80 Oral exposure to atrazine at a dose of 50 of 200 mg kg 21 body weight from postnatal day 23-30 caused downregulation of the expression of the LH receptor gene, reduced cAMP levels, decreased cholesterol transport and decreased 17b-HSD activity. It has been proposed that atrazine inhibits Leydig cell steroidogenesis by inhibiting the expression of genes that are involved in steroidogenesis.…”

mentioning

confidence: 99%

The effect of environmental contaminants on testicular function

Mathur¹,

D’Cruz²

2011

Asian J Androl

161

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mentioning

confidence: 99%

The effect of environmental contaminants on testicular function

Mathur¹,

D’Cruz²

2011

Asian J Androl

161

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“…Low level of plasma testosterone may be due to a direct effect of nickel on the testicular hormonogenesis, which is supported by the decrease in steroidogenic enzyme activities with a concomitant increase in cholesterol and ascorbic acid levels (Table 4, Figures 2 and 3 ). The decrease in plasma testosterone level in protein-restricted experimental groups after nickel sulfate treatment is higher than in the normal dietary protein experimental groups (Table 4) protein intake decreases synthesis of testicular enzymes, lowering the testosterone level, which is further aggravated by exposure of nickel (37). After 15 days of withdrawal from the nickel sulfate treatment, the effects of nickel on testicular cholesterol, ascorbic acid, 3β-HSD, 17β-HSD, and plasma testosterone content were reduced in normal protein-fed as well as protein-restricted dietary groups.…”

Section: Discussionmentioning

confidence: 89%

Effect of nickel sulfate on testicular steroidogenesis in rats during protein restriction.

Das

Dasgupta

2002

Environ Health Perspect

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Nickel, a widely used heavy metal, exerts potent toxic effects on peripheral tissues as well as on the reproductive system. Low dietary protein coupled with exposure to this metal induces more severe changes, including biochemical defects, structural disorders, and altered physiologic functions. This study was designed to assess the effects of nickel sulfate on testicular steroidogenesis and to ascertain whether such alterations are reversible with normal protein and protein-restricted dietary regime. Nickel sulfate [2 mg/100 g body weight (bw)] dissolved in double-distilled water was administered on alternate days for 10 doses in a normal protein diet (18% casein) and a protein-restricted diet (5% casein) to Wistar male albino rats (bw 160 +/- 5 g). Two groups, one with a normal protein diet and the other with a protein-restricted diet, served as controls. Twenty-four hours after the last treatment, all the animals except those in withdrawal groups were sacrificed by decapitation. We observed a significant reduction in the activities of the testicular steroidogenic enzymes and plasma testosterone concentration accompanied by a significant elevation in cholesterol and ascorbic acid level in both dietary groups. After 15 days of withdrawal from the nickel sulfate treatment, the testicular steroidogenic enzymes, along with plasma testosterone level, improved significantly in both normal protein-fed and protein-restricted dietary groups. The effects of nickel on testicular cholesterol and ascorbic acid concentration were also reduced after withdrawal. Our results indicate that nickel sulfate affects the steroidogenic enzymes, causing alteration in the formation of testosterone in both dietary groups, which was manifested in the elevated cholesterol and ascorbic acid level with decreased activities of steroidogenic enzymes in adult rats testes. However, these alterations were reversible in both groups of animals fed normal protein diets and protein-restricted diets.

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“…Reduction in testosterone content (Oishi, Morita & Fukuda, 1978) and reduction in the histochemical reaction of the testicular steroidogenic enzymes 3ß-HSD and 17ß-HSD (Shivanandappa & Krishanakumari, 1983) have also been reported follow¬ ing treatment with different organochlorine com¬ pounds in rats. We have also recently found that aldrin has an inhibitory effect on testicular 3ß-HSD and 17ß-HSD activity (Chatterjee et al 1988). …”

Section: Discussionmentioning

confidence: 94%

“…The effect of different organochlorine compounds on testicular steroidogenesis and sperma¬ togenesis was previously evaluated mainly by gross histological examination of testicular tissue (Datta & Dikshith, 1973;Nigam, Lakkad, Karnik et al 1979) and by comparing the histochemical reaction intensity of different steroidogenic enzymes (Shivanandappa & Krishanakumari, 1983). Aldrin treatment has been found recently to have an inhibitory effect on the activity of the testicular steroidogenic enzymes 3ß-hydroxysteroid dehydrogenase (3ß-HSD) and 17ß-HSD, and to reduce the weight of the testes and accessory sex glands (Chatterjee, Ray, Bagchi & Deb, 1988).…”

Section: Introductionmentioning

confidence: 99%

Effect of aldrin on spermatogenesis, plasma gonadotrophins and testosterone, and testicular testosterone in the rat

Chatterjee

Ray²,

Ghosh³

et al. 1988

Journal of Endocrinology

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Quantitative evaluation of the different varieties of germ cells at stage VII of the seminiferous epithelium cycle, namely type-A spermatogonia (ASg), preleptotene spermatocytes (pLSc), mid-pachytene spermatocytes (mPSc) and step 7 spermatids (7Sd), along with radioimmunoassay of plasma gonadotrophins (FSH and LH), testosterone and testicular testosterone were performed in Wistar rats following treatment with aldrin (polycyclic chlorinated hydrocarbon insecticide) for approximately one (13 days) or two cycles (26 days) of the seminiferous epithelium. Extensive degeneration of all varieties of germ cells at stage VII, reduction in the sperm count and significant reductions in plasma concentrations of LH and testosterone were observed following aldrin treatment. The reduction in plasma concentrations of FSH was statistically significant only after treatment for two cycles. The inhibitory effect of aldrin on plasma gonadotrophins, testosterone levels, testicular testosterone content and numbers of 7Sd and ASg was maximum after treatment for two cycles. Administration of human chorionic gonadotrophin along with aldrin treatment for two cycles partially prevented the degeneration of germ cells and enhanced testosterone production. The results indicate that aldrin may have a direct inhibitory influence on gonadotrophin release, but the possibility of a direct action of the insecticide at the level of the testes is also discussed.

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Suppression of testicular steroidogenesis in rats by the organochlorine insecticide Aldrin

Cited by 16 publications

References 11 publications

The effect of environmental contaminants on testicular function

The effect of environmental contaminants on testicular function

Effect of nickel sulfate on testicular steroidogenesis in rats during protein restriction.

Effect of aldrin on spermatogenesis, plasma gonadotrophins and testosterone, and testicular testosterone in the rat

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