Suppression of T cell responses in the tumor microenvironment

Frey, Alan B.

doi:10.1016/j.vaccine.2015.08.096

Cited by 49 publications

(42 citation statements)

References 95 publications

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“…Several kinds, compositions, and modes of administration of anti-tumor vaccines have been used with different results [160,161,162,163,164,165,166,167]. More recently, the focus of anti-tumor vaccines has been moved from tumor cells to TME too [7,9,10,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150,151,152,153,154,155,156,157,158,159,160,161,162,163,164,165,166,167,168,169,170,171,172,173,174,175]. Indeed, the possibility of targeting tumor endothelial cells or the VEGF signaling axis with specific vaccines has been assessed in preclinical studies, and clinical trials are ongoing [168].…”

Section: Msc As Target Cells For Anti-tumor Vaccinesmentioning

confidence: 99%

Mesenchymal Stromal Cells Can Regulate the Immune Response in the Tumor Microenvironment

Poggi

Giuliani

2016

Vaccines

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The tumor microenvironment is a good target for therapy in solid tumors and hematological malignancies. Indeed, solid tumor cells’ growth and expansion can influence neighboring cells’ behavior, leading to a modulation of mesenchymal stromal cell (MSC) activities and remodeling of extracellular matrix components. This leads to an altered microenvironment, where reparative mechanisms, in the presence of sub-acute inflammation, are not able to reconstitute healthy tissue. Carcinoma cells can undergo epithelial mesenchymal transition (EMT), a key step to generate metastasis; these mesenchymal-like cells display the functional behavior of MSC. Furthermore, MSC can support the survival and growth of leukemic cells within bone marrow participating in the leukemic cell niche. Notably, MSC can inhibit the anti-tumor immune response through either carcinoma-associated fibroblasts or bone marrow stromal cells. Experimental data have indicated their relevance in regulating cytolytic effector lymphocytes of the innate and adaptive arms of the immune system. Herein, we will discuss some of the evidence in hematological malignancies and solid tumors. In particular, we will focus our attention on the means by which it is conceivable to inhibit MSC-mediated immune suppression and trigger anti-tumor innate immunity.

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Section: Msc As Target Cells For Anti-tumor Vaccinesmentioning

confidence: 99%

Mesenchymal Stromal Cells Can Regulate the Immune Response in the Tumor Microenvironment

Poggi

Giuliani

2016

Vaccines

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“…Apart from focal adhesion, another biological process involving cell-cell interaction, T cell receptor signaling pathway ( hsa04660 ), was also extracted in this study. It has been widely reported that the T cell receptor signaling pathway has been blocked or abnormally regulated in tumor microenvironment [90]. In pancreatic cancer, the initiation and progression of pancreatic cancer also interfere with the normal function of T cell receptor.…”

Section: Resultsmentioning

confidence: 99%

Analysis of Important Gene Ontology Terms and Biological Pathways Related to Pancreatic Cancer

Yin

Wang

Zhang

et al. 2016

BioMed Research International

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Pancreatic cancer is a serious disease that results in more than thirty thousand deaths around the world per year. To design effective treatments, many investigators have devoted themselves to the study of biological processes and mechanisms underlying this disease. However, it is far from complete. In this study, we tried to extract important gene ontology (GO) terms and KEGG pathways for pancreatic cancer by adopting some existing computational methods. Genes that have been validated to be related to pancreatic cancer and have not been validated were represented by features derived from GO terms and KEGG pathways using the enrichment theory. A popular feature selection method, minimum redundancy maximum relevance, was employed to analyze these features and extract important GO terms and KEGG pathways. An extensive analysis of the obtained GO terms and KEGG pathways was provided to confirm the correlations between them and pancreatic cancer.

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“…However, most of human tumors proliferate in spite of the presence of tumor associated antigen-specific T cells. In fact, tumor microenvironment may impose several limitations to dampen T-cell immunity (142) and deplete crucial nutrient availability and handling, such as glucose or amino acids (143). It can also stimulate conserved negative feedback mechanisms, such as through PD-1 (144).…”

Section: Tumor Microenvironment Abrogates T-cell Metabolic and Immunementioning

confidence: 99%

Impact of Metabolism in on T-Cell Differentiation and Function and Cross Talk with Tumor Microenvironment

2017

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The immune system and metabolism are highly integrated and multilevel interactions between metabolic system and T lymphocyte signaling and fate exist. Accumulating evidence indicates that the regulation of nutrient uptake and utilization in T cells is critically important for the control of their differentiation and manipulating metabolic pathways in these cells can shape their function and survival. This review will discuss some potential cell metabolism pathways involved in shaping T lymphocyte function and differentiation. It will also describe show subsets of T cells have specific metabolic requirements and signaling pathways that contribute to their respective function. Examples showing the apparent similarity between cancer cell metabolism and T cells during activation are illustrated and finally some mechanisms being used by tumor microenvironment to orchestrate T-cell metabolic dysregulation and the subsequent emergence of immune suppression are discussed. We believe that targeting T-cell metabolism may provide an additional opportunity to manipulate T-cell function in the development of novel therapeutics.

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Suppression of T cell responses in the tumor microenvironment

Cited by 49 publications

References 95 publications

Mesenchymal Stromal Cells Can Regulate the Immune Response in the Tumor Microenvironment

Mesenchymal Stromal Cells Can Regulate the Immune Response in the Tumor Microenvironment

Analysis of Important Gene Ontology Terms and Biological Pathways Related to Pancreatic Cancer

Impact of Metabolism in on T-Cell Differentiation and Function and Cross Talk with Tumor Microenvironment

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