Suppression of Systemic Lupus Erythematosus Disease in Mice by Oral Administration of Kidney Extract

Entwicklung eines systemischen Lupus erythematodes mit fokaler proliferativer Lupusnephritis unter einer Anti-TNF-α-Therapie bei Psoriasisarthritis

“…Im Tiermodell eines Lupus erythematodes führte die exogene Zufuhr von TNF-α zur verzögerten Entwicklung einer Lupusnephritis und zu einem verbesserten Überleben [14], während die renale Hochregulation der Expression von TNF-α die Entwicklung einer Lupusnephritis komplett supprimierte [15]. Umgekehrt führte eine verminderte TNF-α-Produktion zu verstärkter Autoimmunität und Nierenbeteiligung, so dass TNF-α mögli-cherweise eine physiologische Rolle bei der Unterdrückung autoreaktiver Lymphozyten in diesen Modellen zukommt [16].…”

T‐Helper Cell Tolerance to Ubiquitous Nuclear Antigens

“…Regarding CD4 + CD25 + suppressor cells in lupus‐prone mice, although there was no evidence of impairment in or deficiency of CD4 + CD25 + T reg in NZM2328 mice, as discussed above, failure of the cells to modify disease when transferred into day 3‐thymectomized NZM2328 recipients suggests that their regulatory capacity may be hampered in this model [151]. In regard to the ability to induce TGF‐β‐secreting Th3 cells in lupus‐prone mice, at least one group has shown successful suppression of kidney disease by oral administration of kidney extract to (NZB × NZW)F1 mice [175], indicating that this pathway is intact in these animals. Another group showed effective tolerance induction to nucleosomes in SNF1 mice treated with intranasal administration of a peptide containing the dominant T‐cell epitope of histone protein H‐4 [176].…”

Update: Treatment of systemic lupus erythematosus

“…Oral tolerance has been attempted for RA by ingestion of chicken collagen. It has also been attempted in NZB × NZW F1 mice orally given a rat‐kidney extract that would include the putative kidney antigen of nephritogenic SLE autoantibodies (12). This form of treatment resulted in decreased anti–double‐stranded (ds) DNA antibodies, reduced kidney damage, and prolonged survival as compared to controls.…”