Suppression of sweet sensing with glucose, but not aspartame, delays gastric emptying and glycemic response

Kashima, Hideaki; Taniyama, Kana; Sugimura, Kana; Endo, Mitsuharu; Kobayashi, Toshio; Fukuba, Yoshiyuki

doi:10.1016/j.nutres.2019.06.005

Cited by 6 publications

(14 citation statements)

References 29 publications

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“…To maintain the suppressive level of OSS during consuming each sweet-tasting food, we repeatedly stimulated the oral cavity with pre-treatment (i.e., GS solution) just before consuming each sweet-tasting food. The concentrations of the pretreatment solutions were based on the findings from our previous studies [12,13]. This protocol has been designed to reliably suppress OSS and to consider the duration time of the oral stimulus [12,13].…”

Section: Study Protocolmentioning

confidence: 99%

“…The concentrations of the pretreatment solutions were based on the findings from our previous studies [12,13]. This protocol has been designed to reliably suppress OSS and to consider the duration time of the oral stimulus [12,13]. All fluids (pretreatment solutions, water containing 13 C sodium acetate and water used for gargling) were at a room temperature (25 ± 1 • C).…”

Section: Study Protocolmentioning

confidence: 99%

“…This protocol has been designed to reliably suppress OSS and to consider the duration time of the oral stimulus [12,13]. All fluids (pretreatment solutions, water containing 13 C sodium acetate and water used for gargling) were at a room temperature (25 ± 1 • C). Scheme of the protocol of the study.…”

Section: Study Protocolmentioning

confidence: 99%

“…GS is a plant able to selectively suppress the sweet taste sensation in humans [24,25]. We found that GS-dependent suppression of OSS during ingestion of pure glucose solution slowed gastric emptying rate and glycemic response [12,13]. However, it is unknown whether suppressing OSS during consumption of a real sweet food affects both sweet taste liking and CPRs.…”

Section: Introductionmentioning

confidence: 99%

“…When oral sweet receptor activation is suppressed during eating sweet-tasting food, gastric emptying may be delayed. This is because we have actually found that suppression of OSS during ingestion of glucose has a role in decreasing the gastric emptying and slowing blood glucose (BG) and insulin responses [12,13]. Therefore, to elucidate the role of suppression of OSS in decreased sweet-tasting food consumption, we should examine various physiological responses both during and after the prandial phase of consuming a uniform meal in a laboratory-based basic science approach.…”

Section: Introductionmentioning

confidence: 99%

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Suppression of Oral Sweet Sensations during Consumption of Sweet Food in Humans: Effects on Gastric Emptying Rate, Glycemic Response, Appetite, Food Satisfaction and Desire for Basic Tastes

et al. 2020

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Suppression of oral sweet sensation (OSS) acutely reduces intake of sweet-tasting food due to lower liking. However, little is known about other physiological responses during both the prandial and postprandial phase. Here, we explored the effects of Gymnema sylvestre (GS)-based suppression of OSS of several types of sweet-tasting food (muffin, sweet yogurt, banana) on gastric emptying, blood glucose (BG), plasma insulin (PI), appetite indices (hunger, fullness and prospective consumption), satisfaction and desire for tastes. Fifteen healthy subjects (22 ± 3 years, 9 women) took part in the study. Subjects rinsed their mouth with either GS solution or distilled water before eating the sweet-tasting food. Subjects felt decreased sweet taste intensity and reduced taste liking associated with GS rinsing after consuming each food, compared with rinsing with distilled water (p < 0.05). Gastric emptying, BG, PI and appetite indices during and after the prandial phase did not significantly change with GS rinsing compared to rinsing with distilled water (p > 0.05). Higher desire for sweet taste as well as lower satisfaction (p < 0.05) in the postprandial phase were observed with GS rinsing. These results suggest that the suppression of OSS does not affect gastric emptying, glycemic response and appetite during and after consumption of sweet-tasting food.

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