Suppression of secondary generalization of limbic seizures by stimulation of subthalamic nucleus in rats

Usui, Naotaka; Maesawa, Satoshi; Kajita, Yasukazu; Endo, Otone; Takebayashi, Shigenori; Yoshida, Jun

doi:10.3171/jns.2005.102.6.1122

Cited by 57 publications

(34 citation statements)

References 26 publications

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“…Dinner, 2002Shon et al, 2004;Usui et al, 2005). The effect of DBS of the STN is presumably to induce local inhibition in the STN, which in turn reduces excitatory input to the SNr.…”

Section: Discussionmentioning

confidence: 99%

Temporal sequence of ictal discharges propagation in the corticolimbic basal ganglia system during amygdala kindled seizures in freely moving rats

Shi

Luo

Woodward³

et al. 2007

Epilepsy Research

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We used a multiple channel, single unit recording technique to investigate the neural activity in different corticolimbic and basal ganglia regions in freely moving rats before and during generalized amygdala kindled seizures. Neural activity was recorded simultaneously in the sensorimotor cortex (Ctx), hippocampus, amygdala, substantia nigra pars reticulata (SNr) and the subthalamic nucleus (STN). We observed massive synchronized activity among neurons of different brain regions during seizure episodes. Neurons in the kindled amygdala led other regions in synchronized firing, revealed by time lags of neurons in other regions in crosscorrelogram analysis. While there was no obvious time lag between Ctx and SNr, the STN and hippocampus did lag behind the Ctx and SNr in correlated firing. Activity in the amygdala and SNr contralateral to the kindling stimulation site lagged behind their ipsilateral counterparts. However no time lag was found between the kindling and contralateral sides of Ctx, hippocampus and STN. Our data confirm that the amygdala is an epileptic focus that emits ictal discharges to other brain regions. The observed temporal pattern indicates that ictal discharges from the amygdala arrive first at Ctx and SNr, and then spread to the hippocampus and STN. The simultaneous activation of both sides of the Ctx suggests that the neocortex participates in kindled seizures as a unisonant entity to provoke the clonic motor seizures. Early activation of the SNr (before the STN and hippocampus) points to an important role of the SNr in amygdala kindled seizures and supports the view that different SNr manipulations may be effective ways to control seizures.

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“…Dinner, 2002Shon et al, 2004;Usui et al, 2005). The effect of DBS of the STN is presumably to induce local inhibition in the STN, which in turn reduces excitatory input to the SNr.…”

Section: Discussionmentioning

confidence: 99%

Temporal sequence of ictal discharges propagation in the corticolimbic basal ganglia system during amygdala kindled seizures in freely moving rats

Shi

Luo

Woodward³

et al. 2007

Epilepsy Research

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“…Recent studies also suggested that STN DBS could be useful in the treatment of epilepsy in animal mod-els (Usui et al, 2005) as well as in human (Chabardes et al, 2002;Lee et al, 2006). It consists of delivering electrical pulses within the STN through an implanted electrode connected to an implanted pulse generator (IPG) .…”

Section: Introductionmentioning

confidence: 99%

Influence of the implanted pulse generator as reference electrode in finite element model of monopolar deep brain stimulation

Walckiers

Fuchs

Thiran

et al. 2010

Journal of Neuroscience Methods

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a b s t r a c tElectrical deep brain stimulation (DBS) is an efficient method to treat movement disorders. Many models of DBS, based mostly on finite elements, have recently been proposed to better understand the interaction between the electrical stimulation and the brain tissues. In monopolar DBS, clinically widely used, the implanted pulse generator (IPG) is used as reference electrode (RE).In this paper, the influence of the RE model of monopolar DBS is investigated. For that purpose, a finite element model of the full electric loop including the head, the neck and the superior chest is used. Head, neck and superior chest are made of simple structures such as parallelepipeds and cylinders. The tissues surrounding the electrode are accurately modelled from data provided by the diffusion tensor magnetic resonance imaging (DT-MRI). Three different configurations of RE are compared with a commonly used model of reduced size.The electrical impedance seen by the DBS system and the potential distribution are computed for each model. Moreover, axons are modelled to compute the area of tissue activated by stimulation.Results show that these indicators are influenced by the surface and position of the RE. The use of a RE model corresponding to the implanted device rather than the usually simplified model leads to an increase of the system impedance (+48%) and a reduction of the area of activated tissue (−15%).

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“…In contrast Usui et al 75 found no treatment effect when they tested SNr DBS in rats with kainic acid-induced seizures. They compared a group of rats with a unilateral SNr electrode to a a group with a unilateral STN electrode.…”

Section: Stimulation Of the Stn And Snrmentioning

confidence: 96%

“…36,49,62,67,75,90,91 Animal epilepsy models have utilized pentylenetetrazol, kainic acid, bicuculline, picrotoxin, and kindling to induce seizures. 36,49,57,62,67,75,91 Sinusoidal AC versus DC stimulation protocols, synaptic versus nonsynaptic inhibition, regional alterations in neurochemistry, and different anatomic targets are among the many variables investigated in these models. 36,49,62,91 Finding effective targets for modulating epileptiform activity is arguably the most important, but most elusive variable in the quest to treat seizures with DBS.…”

Section: Animal Studiesmentioning

confidence: 99%

Deep brain stimulation for medically refractory epilepsy

Ellis¹,

Stevens²

2008

FOC

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Epilepsy is a chronic neurological disorder that affects 0.5–1% of the population. Up to one-third of patients will have incompletely controlled seizures or debilitating side effects of anticonvulsant medications. Although some of these patients may be candidates for resection, many are not. The desire to find alternative treatments for epilepsy has led to a resurgence of interest in the use of deep brain stimulation (DBS), which has been used quite successfully in movement disorders. Small pilot studies and open-label trials have yielded results that may support the use of DBS in selected patients with refractory seizures. Because of the diversity of regions involved with seizure initiation and propagation, a variety of targets for stimulation have been examined. Moreover, stimulation parameters such as amplitude, frequency, pulse duration, and continuous versus intermittent on vary from one study to the next. More studies are necessary to determine if there is an appropriate population of seizure patients for DBS, the optimal target, and the most efficacious stimulation parameters.

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Suppression of secondary generalization of limbic seizures by stimulation of subthalamic nucleus in rats

Cited by 57 publications

References 26 publications

Temporal sequence of ictal discharges propagation in the corticolimbic basal ganglia system during amygdala kindled seizures in freely moving rats

Temporal sequence of ictal discharges propagation in the corticolimbic basal ganglia system during amygdala kindled seizures in freely moving rats

Influence of the implanted pulse generator as reference electrode in finite element model of monopolar deep brain stimulation

Deep brain stimulation for medically refractory epilepsy

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