Suppression of Penicillin G Procaine Solubility in Aqueous Media

β-Lactam Antibiotics: Their Physicochemical Properties and Biological Activities in Relation to Structure

“…Swintosky et al (140,141) demonstrated that the degradation of a procaine-penicillin G suspension is of zero order, since only the material in solution degrades, and that the decreased solubility could be utilized to stabilize the penicillins.…”

Preparation of Oral Penicillin G Procaine Suspensions of Extended Shelf Life

“…Suspensions containing 60,000 and 100,000 penicillin u./cc., respectively, were kept in stoppered 60-c~. flint-glass bottles in dark storage rooms for several months at 27" ( 1 3 9 , 4 3 ' (=I=Zo) and 56" ( =!=Z0) ; and periodically were assayed in duplicate by a microbiologic method (1).…”

“…ANGECKER, Schiimann, and Junkmann (1) recently studied a number of compounds of the class of carbamic acid esters of tertiaryunsaturated carbinols with respect to their hypnotic action, and found a derivative which proved to be sleep producing in animal experiments. This compound was ethinylcyclohexyl carbamic acid ester with the following chemical structure: The material is a stable crystalline powder with a melting point of 9f3-98".…”

A Kinetic Study of the Specific Hydrogen Ion Catalyzed Solvolysis of Chloramphenicol in Water-Propylene Glycol Systems**College of Pharmacy, Rutgers University, Newark 4, N. J.

“…Drugs of such diverse chemical constitution as procaine, aluminum acetate, naphazoline, and chloramphenicol are all subject to hydrolytic breakdown (1-4) and these liabilities are often important in formulation procedures. In many instances solvolysis may be inhibited, or avoided entirely, by a variety of remedies including judicious maintenance of pH (1, a), "tying up" the labile species in the form of a stable complex ( 5 ) , the use of an insoluble form of the active ingredient (6), or by careful control of buffer capacity and constituents ( 7 ) .…”