Suppression of Pathogenicity by P and V Plasmids in Vibrio cholerae

Abstract

In experimental models of cholera, some strains of Vibrio cholerae harbouring P or V or both plasmids were markedly less pathogenic than isogenic strains devoid of these plasmids. This effect was due to decreased production of toxin by P+, V+ or P+V+ bacteria compared with their parents.

Genetics of Vibrio cholerae and its bacteriophages.

“…No simple phenotypic markers have been identified on P. However, P has been implicated in the suppression of the pathogenicity of V. cholerae (115). This is thought to be due to a decreased production of cholera toxin.…”