Suppression of palmitic acid-induced hepatic oxidative injury by neohesperidin-loaded pectin-chitosan decorated nanoliposomes

Karim, Naymul; Shishir, Mohammad Rezaul Islam; Rashwan, Ahmed K.; Ke, Huihui; Chen, Wei

doi:10.1016/j.ijbiomac.2021.05.010

Cited by 28 publications

(11 citation statements)

References 57 publications

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“…In addition, gallic acid is an effective inhibitor of collagenase, elastase, and MMP-2 activity ( Wittenauer et al., 2015 ; Poomanee et al., 2021 ). Caffeic acid has been found to be an effective inhibitor of collagenase and MMP-1 activity ( Shin et al., 2019 ; Saechan et al., 2021 ), and neohesperidin reduces MMP-1 activity ( Karim et al., 2021 ). Naringin has been discovered to significantly inhibit the production of elastase or downregulate MMP-2 expression ( Annapoorani et al., 2012 ; Aroui et al., 2016 ).…”

Section: Resultsmentioning

confidence: 99%

Submerged fermentation with Lactobacillus brevis significantly improved the physiological activities of Citrus aurantium flower extract

Chen

et al. 2022

Heliyon

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Section: Resultsmentioning

confidence: 99%

Submerged fermentation with Lactobacillus brevis significantly improved the physiological activities of Citrus aurantium flower extract

Chen

et al. 2022

Heliyon

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“…The hydrolysis of phosphatidylcholine under aqueous conditions can reduce EE, leading to the aggregation and fusion of conventional liposomes. Furthermore, temperature can disrupt the acyl side chain of the phospholipid bilayer, thereby increasing liposomal membrane fluidity and permeability, leading to drug release (Karim et al, 2021). However, natural polymer coatings can reduce membrane fluidity and drug leakage via various factors to improve EE.…”

Section: Improved Encapsulation Efficiencymentioning

confidence: 99%

“…These findings may be attributable to the low fluidity of the coating which impedes drug diffusion into the release medium, thus reducing membrane permeability and enhancing total drug efficacy (Li, Deng, et al, 2017). For instance, at pH 7.4, the drug release rate was significantly higher in uncoated than coated liposomes (Karim et al, 2021). CS coating can prevent rapid drug release due to gastric acid degradation (Sağıroğlu, 2021; Zhou et al, 2021).…”

Section: Characteristics Of Polysaccharide‐coated Liposomal Drug Deli...mentioning

confidence: 99%

“…Wang et al (2021) found that a high concentration of CS (>2 mg/ml) improved EE compared to that of uncoated liposomes, suggesting that CS added a physical barrier to liposomal membranes. Karim et al (2021) found that the EE of CS plus pectin‐coated liposomes was significantly improved compared to those of single‐CS coated or uncoated liposomes. (Gottesmann et al, 2020) also reported that EE was higher in pectin‐coated than in uncoated liposomes.…”

Section: Characteristics Of Polysaccharide‐coated Liposomal Drug Deli...mentioning

confidence: 99%

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Polysaccharide‐modified liposomes and their application in cancer research

Peng

Chen²,

Wang

et al. 2023

Chem Biol Drug Des

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Nanodrug delivery systems have been widely used in cancer treatment. Among these, liposomal drug carriers have gained considerable attention due to their biocompatibility, biodegradability, and low toxicity. However, conventional liposomes have several shortcomings, such as poor stability, rapid clearance, aggregation, fusion, degradation, hydrolysis, and oxidation of phospholipids. Polysaccharides are natural polymers of biological origin that exhibit structural stability, excellent biocompatibility and biodegradability, flexibility, non‐immunogenicity, low toxicity, and targetability. Therefore, they represent a promising class of polymers for the modification of the surface properties of liposomes to overcome their shortcomings. In addition, polysaccharides can be readily combined with other materials to develop new composite materials. Hence, they represent the optimal choice for liposomal modification to improve pharmacokinetics and clinical utility. Polysaccharide‐coated liposomes exhibit better stability, drug release kinetics, and cellular uptake than conventional liposomes. The oncologic application of polysaccharide‐coated liposomes has become a research hotspot. We summarize the preparation, physicochemical properties, and antineoplastic effects of polysaccharide‐coated liposomes to facilitate antitumor drug development.

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“…Thanks to the remarkable advances in nanotechnology, numerous formulations and/or carriers have been developed to enhance the bioavailability and thus efficacy of bioactive phytochemicals (Karim et al, 2020(Karim et al, , 2021Sarwar et al, 2020;Shishir, Karim, Gowd, Xie, et al, 2019;Wan et al, 2018). These carrier systems can be varied in terms of functional properties (e.g., active targeting, passive targeting, and theranostic) and routes of administration (e.g., oral, injectable, topical, ocular, pulmonary, nasal, transmucosal, and implantable) (Alvarez-Lorenzo & Concheiro, 2014;Patra et al, 2018;.…”

Section: Introductionmentioning

confidence: 99%

Advances in smart delivery of food bioactive compounds using stimuli‐responsive carriers: Responsive mechanism, contemporary challenges, and prospects

Shishir

Gowd

Suo

et al. 2021

Comp Rev Food Sci Food Safe

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Many important food bioactive compounds are plant secondary metabolites that have traditional applications for health promotion and disease prevention. However, the chemical instability and poor bioavailability of these compounds represent major challenges to researchers. In the last decade, therefore, major impetus has been given for the research and development of advanced carrier systems for the delivery of natural bioactive molecules. Among them, stimuli-responsive carriers hold great promise for simultaneously improving stability, bioavailability, and more importantly delivery and on-demand release of intact bioactive phytochemicals to target sites in response to certain stimuli or combination of them (e.g., pH, temperature, oxidant, enzyme, and irradiation) that would eventually enhance therapeutic outcomes and reduce side effects. Hybrid formulations (e.g., inorganic-organic complexes) and multi-stimuli-responsive formulations have demonstrated great potential for future studies. Therefore, this review systematically compiles and assesses the recent advances on the smart delivery of food bioactive compounds, particularly quercetin, curcumin, and resveratrol through stimuli-responsive carriers, and critically reviews their functionality, underlying triggered-release mechanism, and therapeutic potential. Finally, major limitations, contemporary challenges, and possible solutions/future research directions are highlighted. Much more research is needed to optimize the processing parameters of existing formulations and to develop novel ones for lead food bioactive compounds to facilitate their food and nutraceutical applications.

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Suppression of palmitic acid-induced hepatic oxidative injury by neohesperidin-loaded pectin-chitosan decorated nanoliposomes

Cited by 28 publications

References 57 publications

Submerged fermentation with Lactobacillus brevis significantly improved the physiological activities of Citrus aurantium flower extract

Submerged fermentation with Lactobacillus brevis significantly improved the physiological activities of Citrus aurantium flower extract

Polysaccharide‐modified liposomes and their application in cancer research

Advances in smart delivery of food bioactive compounds using stimuli‐responsive carriers: Responsive mechanism, contemporary challenges, and prospects

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