Suppression of NK cell-mediated cytotoxicity against PRRSV-infected porcine alveolar macrophages in vitro

Cao, Jun; Grauwet, Korneel; Vermeulen, Ben; Devriendt, Bert; Jiang, Ping; Favoreel, Herman; Nauwynck, Hans

doi:10.1016/j.vetmic.2013.03.001

Cited by 26 publications

(20 citation statements)

References 35 publications

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“…PRRSV does neither; infection does not lead to severe lymphoid depletion or ablation, and it does not interfere profoundly with lymphocyte differentiation or maturation. Leukocyte perturbations in lymphoid tissues are associated with PRRSV infection, suggesting that adaptive immunity might be weakened, though not destroyed [56,57,58,59,60,61]. …”

Section: Immunosuppressionmentioning

confidence: 99%

“…Alternative antibody functions, such as antibody dependent cell-mediated cytotoxicity (ADCC), antibody-dependent complement-mediated cytotoxicity (CDC), and antibody-dependent complement-mediated virolysis may be important in the clearance of virus and virally infected cells from an animal. To our knowledge, there are only two published papers investigating non-neutralizing antibody functions in the context of PRRSV infection [59,132]. Both of these in vitro studies utilized a PRRSV-1 virus and failed to find an effect of ADCC and CDC on infected cells.…”

Section: Antibody Responsementioning

confidence: 99%

“…Furthermore, PRRSV appears to suppress the NK cell response without significantly affecting NK cell numbers [165,166,167,168]. The cause of this suppression has yet to be determined, although viral proteins, rather than soluble factors from cells, may be responsible [59]. Potential roles of additional NK cell functions, such as ADCC, in PRRSV immunity are poorly understood [133].…”

Section: Natural Killer Cell Responsementioning

confidence: 99%

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Mechanisms of Adaptive Immunity to Porcine Reproductive and Respiratory Syndrome Virus

Rahe

Murtaugh

2017

Viruses

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The adaptive immune response is necessary for the development of protective immunity against infectious diseases. Porcine reproductive and respiratory syndrome virus (PRRSV), a genetically heterogeneous and rapidly evolving RNA virus, is the most burdensome pathogen of swine health and wellbeing worldwide. Viral infection induces antigen-specific immunity that ultimately clears the infection. However, the resulting immune memory, induced by virulent or attenuated vaccine viruses, is inconsistently protective against diverse viral strains. The immunological mechanisms by which primary and memory protection are generated and used are not well understood. Here, we summarize current knowledge regarding cellular and humoral components of the adaptive immune response to PRRSV infection that mediate primary and memory immune protection against viruses.

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Section: Immunosuppressionmentioning

confidence: 99%

Section: Antibody Responsementioning

confidence: 99%

Section: Natural Killer Cell Responsementioning

confidence: 99%

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Mechanisms of Adaptive Immunity to Porcine Reproductive and Respiratory Syndrome Virus

Rahe

Murtaugh

2017

Viruses

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“…Therefore, the absence or small numbers of CD8 + cells in the fetal allantochorion may be a reason for the very efficient PRRSV replication (in comparison to the endometrium) [57]. Macrophages infected with PRRSV possess a reduced susceptibility toward peripheral blood NK cytotoxicity in vitro [72]. However, endometrial NK cells are unique and distinct from those from the peripheral blood due to the special immunological environment in the maternal-fetal interface [73,74].…”

Section: Prrsv Infection In the Conceptusmentioning

confidence: 99%

Pathogenesis and prevention of placental and transplacental porcine reproductive and respiratory syndrome virus infection

Karniychuk

Nauwynck

2013

Vet Res

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Porcine reproductive and respiratory syndrome virus (PRRSV)-induced reproductive problems are characterized by embryonic death, late-term abortions, early farrowing and increase in number of dead and mummified fetuses, and weak-born piglets. The virus recovery from fetal tissues illustrates transplacental infection, but despite many studies on the subject, the means by which PRRSV spreads from mother to fetus and the exact pathophysiological basis of the virus-induced reproductive failure remain unexplained. Recent findings from our group indicate that the endometrium and placenta are involved in the PRRSV passage from mother to fetus and that virus replication in the endometrial/placental tissues can be the actual reason for fetal death. The main purpose of this review is to clarify the role that PRRSV replication and PRRSV-induced changes in the endometrium/placenta play in the pathogenesis of PRRSV-induced reproductive failure in pregnant sows. In addition, strategies to control placental and transplacental PRRSV infection are discussed.

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“…Additionally, NK cell function may be influenced by infections. Thus, a decrease in cytolytic activity of porcine NK cells could be observed after ASFV infection (Norley and Wardley, 1983) as well as in PRRSV (Cao et al, 2013;Dwivedi et al, 2012;Jung et al, 2009;Renukaradhya et al, 2010) and porcine respiratory corona virus infections (Jung et al, 2009;Renukaradhya et al, 2010). Moreover decreased lytic function and reduced numbers of IFN-c producing NK cells were found following FMDV infection (Toka et al, 2009a).…”

Section: Natural Killer Cellsmentioning

confidence: 99%

The porcine innate immune system: An update

Mair

Sedlak

Käser

et al. 2014

Developmental & Comparative Immunology

204

157

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Over the last few years, we have seen an increasing interest and demand for pigs in biomedical research. Domestic pigs (Sus scrofa domesticus) are closely related to humans in terms of their anatomy, genetics, and physiology, and often are the model of choice for the assessment of novel vaccines and therapeutics in a preclinical stage. However, the pig as a model has much more to offer, and can serve as a model for many biomedical applications including aging research, medical imaging, and pharmaceutical studies to name a few. In this review, we will provide an overview of the innate immune system in pigs, describe its anatomical and physiological key features, and discuss the key players involved. In particular, we compare the porcine innate immune system to that of humans, and emphasize on the importance of the pig as model for human disease.

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Suppression of NK cell-mediated cytotoxicity against PRRSV-infected porcine alveolar macrophages in vitro

Cited by 26 publications

References 35 publications

Mechanisms of Adaptive Immunity to Porcine Reproductive and Respiratory Syndrome Virus

Mechanisms of Adaptive Immunity to Porcine Reproductive and Respiratory Syndrome Virus

Pathogenesis and prevention of placental and transplacental porcine reproductive and respiratory syndrome virus infection

The porcine innate immune system: An update

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