Suppression of microRNA-18a expression inhibits invasion and promotes apoptosis of human trophoblast cells by targeting the estrogen receptor α gene

Zhu, Xiaoming; Yang, Yang; Han, Tao; Guo, Yijia; Gao, Ping; Ni, Yicheng; Su, Xiaohua; Liu, Yuying; Yao, Yuanqing

doi:10.3892/mmr.2015.3724

Cited by 28 publications

(22 citation statements)

References 25 publications

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“…Thbs1 (thrombospondin 1) is an effective angiogenesis inhibitor 28 whose expression is inhibited by Myc protein 23 and Myc-induced miR-17/92 cluster miRNAs, 29 in particular, miR-18a and miR-19b-1. 30 – 32 To assess whether Thbs1 expression was modulated in E9.5 Sema3f −/− yolk sacs compared with their wild-type counterpart, we first analyzed Thbs1 gene transcription by real-time quantitative polymerase chain reaction (Figure IVB in the online-only Data Supplement ). Compared with wild-type yolk sacs, Thbs1 mRNA levels increased by 1.5-fold in Sema3f −/− yolk sacs.…”

Section: Resultsmentioning

confidence: 99%

Sema3F (Semaphorin 3F) Selectively Drives an Extraembryonic Proangiogenic Program

Regano

Visintin

Clapero

et al. 2017

ATVB

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Section: Resultsmentioning

confidence: 99%

Sema3F (Semaphorin 3F) Selectively Drives an Extraembryonic Proangiogenic Program

Regano

Visintin

Clapero

et al. 2017

ATVB

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show abstract

“…Several reports have shown that miR-18a-5p is related to cell death. Suppression of miR-18a can increase apoptosis ( Fujiya et al ., 2014 ; Zhu et al ., 2015 ). In addition, miR-18a-5p may promote carcinogenesis by directly targeting IRF2 in lung cancer ( Liang et al ., 2017 ) and STK4 in prostate cancer ( Hsu et al ., 2014 ).…”

Section: Discussionmentioning

confidence: 99%

α, γ-Mangostins Induce Autophagy and Show Synergistic Effect with Gemcitabine in Pancreatic Cancer Cell Lines

Kim

Chin

2017

Biomolecules & Therapeutics

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Pancreatic cancer is one of the most lethal and aggressive cancers in the world. However, no effective treatment is currently available for pancreatic cancer. The objective of this study was to determine the anti-pancreatic cancer effect of α-mangostin (αM) and γ-mangostin (γM) extracted from the pericarp of Garcinia mangostana L.. Both αM and γM reduced the viability of pancreatic cancer cells MIA PaCa-2 and PANC-1 in a dose-dependent manner. These compounds induced apoptosis by increasing c-PARP and c-Caspase 3 levels. They also induced autophagy by increasing levels of microtubule-associated protein 1A/1B light chain 3B (LC3II) in both cell lines while decreasing sequestosome 1 (p62) in MIA PaCa-2. Both αM and γM induced autophagy through increasing phosphorylation levels of AMP-activated protein kinase (p-AMPK) and p38-mitogen activated protein kinase (p-p38) while decreasing phosphorylation level of mammalian target of rapamycin complex 1 (p-mTOR). Of various microRNAs (miRNA), miR-18a was found to be a putative regulatory miRNA for autophagy induced by αM or γM. In combination with gemcitabine, a compound frequently used in pancreatic cancer treatment, αM and γM showed synergistic anti-cancer effects in MIA PaCa-2. Collectively, these results suggest that αM and γM can induce apoptosis and autophagy in pancreatic cancer cells and that their anti-cancer effect is likely to be associated with miR-18a. In conclusion, αM and γM might be used as a potential new therapy for pancreatic cancer.

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“…The miR-29 family (miR-29a/b/c) promoted apoptosis by targeting myeloid cell leukemia-1 (MCL1), an apoptosis regulator and a member of the BLC2 family , Gu et al 2016. Overexpression of miR-18a increased apoptosis by inducing the expression of estrogen receptor alpha (ESR1) (Zhu et al 2015), while miR-128a induced apoptosis via the mitochondrial pathway by downregulating BAX (Ding et al 2016) and miR-30a-3p by inhibiting IGF1 (Niu et al 2018). On the other hand, miR-101 targeted endoplasmic reticulum protein 44 (ERP44) to suppress ER-stress-induced apoptosis (Zou et al 2014).…”

Section: Mirnas In Trophoblast Proliferation and Apoptosismentioning

confidence: 99%

MicroRNAs: crucial regulators of placental development

Hayder¹,

O’Brien²,

Nadeem³

et al. 2018

Reproduction

120

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MicroRNAs (miRNAs) are small non-coding single-stranded RNAs that are integral to a wide range of cellular processes mainly through the regulation of translation and mRNA stability of their target genes. The placenta is a transient organ that exists throughout gestation in mammals, facilitating nutrient and gas exchange and waste removal between the mother and the fetus. miRNAs are expressed in the placenta, and many studies have shown that miRNAs play an important role in regulating trophoblast differentiation, migration, invasion, proliferation, apoptosis, vasculogenesis/angiogenesis and cellular metabolism. In this review, we provide a brief overview of canonical and non-canonical pathways of miRNA biogenesis and mechanisms of miRNA actions. We highlight the current knowledge of the role of miRNAs in placental development. Finally, we point out several limitations of the current research and suggest future directions.

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Suppression of microRNA-18a expression inhibits invasion and promotes apoptosis of human trophoblast cells by targeting the estrogen receptor α gene

Cited by 28 publications

References 25 publications

Sema3F (Semaphorin 3F) Selectively Drives an Extraembryonic Proangiogenic Program

Sema3F (Semaphorin 3F) Selectively Drives an Extraembryonic Proangiogenic Program

α, γ-Mangostins Induce Autophagy and Show Synergistic Effect with Gemcitabine in Pancreatic Cancer Cell Lines

MicroRNAs: crucial regulators of placental development

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