Suppression of macrophage function in AK-5 tumor transplanted animals: role of TGF-β1

Mitra, Roshni; Khar, Ashok

doi:10.1016/j.imlet.2003.12.003

Cited by 4 publications

(4 citation statements)

References 29 publications

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“…It is also involved in up-regulating the angiogenic growth factor VEGF [64] and in collagen production (particularly type I and III) and is also a potent inhibitor of metalloproteinases MMP-1, MMP-3 and MMP-9 [61,63,65]. Interestingly, once the wound field is sterilized, TGF-β is able to deactivate superoxide production from macrophages in vitro [66]. This helps to protect the surrounding healthy tissue and prepares the wound for granulation tissue formation [67].…”

Section: Discussionmentioning

confidence: 99%

Skin-Compatible Biobased Beauty Masks Prepared by Extrusion

Coltelli

Panariello

Morganti

et al. 2020

JFB

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In the cosmetic sector, natural and sustainable products with a high compatibility with skin, thus conjugating wellness with a green-oriented consumerism, are required by the market. Poly(hydroxyalkanoate) (PHA)/starch blends represent a promising alternative to prepare flexible films as support for innovative beauty masks, wearable after wetting and releasing starch and other selected molecules. Nevertheless, preparing these films by extrusion is difficult due to the high viscosity of the polymer melt at the temperature suitable for processing starch. The preparation of blends including poly(butylene succinate-co-adipate) (PBSA) or poly(butylene adipate-co-terephthalate) (PBAT) was investigated as a strategy to better modulate melt viscosity in view of a possible industrial production of beauty mask films. The release properties of films in water, connected to their morphology, was also investigated by extraction trials, infrared spectroscopy and stereo and electron microscopy. Then, the biocompatibility with cells was assessed by considering both mesenchymal stromal cells and keratinocytes. All the results were discussed considering the morphology of the films. This study evidenced the possibility of modulating thanks to the selection of composition and the materials processing of the properties necessary for producing films with tailored properties and processability for beauty masks.

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Section: Discussionmentioning

confidence: 99%

Skin-Compatible Biobased Beauty Masks Prepared by Extrusion

Coltelli

Panariello

Morganti

et al. 2020

JFB

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“…TGF‐β1 facilitates the recruitment of additional inflammatory cells and augments macrophage mediated tissue debridement (reviewed in Clark 81 ). It is also interesting to note that once the wound field is sterilized, TGF‐β1 may be able to deactivate superoxide production from macrophages in vitro 100 . This helps to protect the surrounding healthy tissue and prepares the wound for granulation tissue formation 101 .…”

Section: Transforming Growth Factor‐β (Tgf‐β) Familymentioning

confidence: 99%

“…It is also interesting to note that once the wound field is sterilized, TGF-b1 may be able to deactivate superoxide production from macrophages in vitro. 100 This helps to protect the surrounding healthy tissue and prepares the wound for granulation tissue formation. 101 In vitro studies show that TGF-b1 helps initiate granulation tissue formation by increasing the expression of genes associated with ECM formation including fibronectin, the fibronectin receptor, and collagen and protease inhibitors.…”

Section: Transforming Growth Factor-b (Tgf-b) Familymentioning

confidence: 99%

PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing

Barrientos

Stojadinović

Golinko

et al. 2008

Wound Repair Regeneration

2,982

2,478

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Wound healing is an evolutionarily conserved, complex, multicellular process that, in skin, aims at barrier restoration. This process involves the coordinated efforts of several cell types including keratinocytes, fibroblasts, endothelial cells, macrophages, and platelets. The migration, infiltration, proliferation, and differentiation of these cells will culminate in an inflammatory response, the formation of new tissue and ultimately wound closure. This complex process is executed and regulated by an equally complex signaling network involving numerous growth factors, cytokines and chemokines. Of particular importance is the epidermal growth factor (EGF) family, transforming growth factor beta (TGF‐β) family, fibroblast growth factor (FGF) family, vascular endothelial growth factor (VEGF), granulocyte macrophage colony stimulating factor (GM‐CSF), platelet‐derived growth factor (PDGF), connective tissue growth factor (CTGF), interleukin (IL) family, and tumor nerosis factor‐α family. Currently, patients are treated by three growth factors: PDGF‐BB, bFGF, and GM‐CSF. Only PDGF‐BB has successfully completed randomized clinical trials in the Unites States. With gene therapy now in clinical trial and the discovery of biodegradable polymers, fibrin mesh, and human collagen serving as potential delivery systems other growth factors may soon be available to patients. This review will focus on the specific roles of these growth factors and cytokines during the wound healing process.

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“…TGF signalling can also limit chemokine and cytokine production by immune cells, in particular T lymphocytes and activated macrophages (Letterio, 2005;Yang et al, 2010). In particular, TGF is a potent suppressor of the antimicrobial activity of macrophages; this is manifest via TGF -mediated suppression of cytotoxic activity, superoxide production and nitric oxide synthase (iNOS) activity (Mitra & Khar, 2004). This increase in TGF during sepsis can therefore suppress secondary antimicrobial responses by macrophages, limiting the ability of these cells to respond to secondary infections.…”

Section: Early Phase Cars: Suppressor Cells and Immunosuppressive Cytmentioning

confidence: 99%