Suppression of lymphocyte blastogenesis to mitogens in cats experimentally infected with feline immunodeficiency virus

Lin, Dah-Sheng; Bowman, Dwight D.; Jacobson, Richard H.; Barr, Margaret C.; Fevereiro, Miguel; Jl, Williams; Noronha, Fernando de; Scott, F. W.; Avery, R. J.

doi:10.1016/0165-2427(90)90066-2

Cited by 43 publications

(22 citation statements)

References 11 publications

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“…Clinical monitoring was not measured intensively after this time, as all cats were consistently clinically normal. Blood samples were obtained by venipuncture of the jugular or cephalic vein on study days (relative to virus exposure) Ϫ1, 3,7,10,15,22,29,35,42,49,64,79,91,107,114,135,171,184,198,233,240,247,254, and 259.…”

Section: Methodsmentioning

confidence: 99%

Puma Lentivirus Is Controlled in Domestic Cats after Mucosal Exposure in the Absence of Conventional Indicators of Immunity

TerWee

Yactor

Sondgeroth

et al. 2005

J Virol

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A high percentage of free-ranging pumas (Felis concolor) are infected with feline lentiviruses (puma lentivirus, feline immunodeficiency virus Pco [FIV-Pco], referred to here as PLV) without evidence of disease. PLV establishes productive infection in domestic cats following parenteral exposure but, in contrast to domestic cat FIV, it does not cause T-cell dysregulation. Here we report that cats exposed to PLV oro-nasally became infected yet rapidly cleared peripheral blood mononuclear cell (PBMC) proviral load in the absence of a correlative specific immune response. Two groups of four specific-pathogen-free cats were exposed to PLV via the mucosal (oro-nasal) or parenteral (i.v.) route. All animals were PBMC culture positive and PCR positive within 3 weeks postinfection and seroconverted without exhibiting clinical disease; however, three or four oro-nasally infected animals cleared circulating proviral DNA within 3 months. Antibody titers reached higher levels in animals that remained persistently infected. PLV antigen-induced proliferation was slightly greater in mucosally inoculated animals, but no differences were noted in cytotoxic T-lymphocyte responses or cytokine profiles between groups. The distribution of virus was predominantly gastrointestinal as opposed to lymphoid in all animals in which virus was detected at necropsy. Possible mechanisms for viral clearance include differences in viral fitness required for crossing mucosal surfaces, a threshold dose requirement for persistence, or an undetected sterilizing host immune response. This is the first report of control of a productive feline or primate lentivirus infection in postnatally exposed, seropositive animals. Mechanisms underlying this observation will provide clues to containment of immunodeficiency disease and could prompt reexamination of vaccine-induced immunity against human immunodeficiency virus and other lentiviruses.

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Section: Methodsmentioning

confidence: 99%

Puma Lentivirus Is Controlled in Domestic Cats after Mucosal Exposure in the Absence of Conventional Indicators of Immunity

TerWee

Yactor

Sondgeroth

et al. 2005

J Virol

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“…amounts of individual lymphocyte subsets, decreases in lymphocyte blastogenesis responses to concanavalin A, pokeweed mitogen and phytohaemagglutinin, and in primary responses to T cell-dependent antigens were observed (Lin et al, 1990;Siebelink et al, 1990;Taniguchi et al, 1990Taniguchi et al, , 1991Torten et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

Comparative study of the cell tropism of feline immunodeficiency virus isolates of subtypes A, B and D classified on the basis of the env gene V3-V5 sequence

Hohdatsu

Hirabayashi

Motokawa

et al. 1996

Journal of General Virology

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“…Thus, it is thought that follicular depletion in the lymph nodes and lymphocyte depletion in peripheral blood are associated with development of AIDS in FIV-infected cats [2,4,18,39,42]. Although the numbers of peripheral blood CD4 positive (CD4 + ) cells and the CD4/CD8 ratio are reported to decrease in FIV-infected cats [1,2,8,27,42,44], the alteration of the T-cell subset in the lymph nodes of FIV-infected cats has not been vigorously studied.…”

mentioning

confidence: 99%

Alteration of T-Cell Subsets in the Lymph Nodes from Cats Infected with Feline Immunodeficiency Virus

Endo

Matsumura

Washizu

et al. 1997

The Journal of Veterinary Medical Science

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ABSTRACT. Alterations of T-cell subsets in the lymph nodes from FIV-infected cats in various clinical disease stages were examined histologically. In the early stage of infection (AP stage), follicular hyperplasia accompanied by expansion of the paracortical area was observed. Follicular involution and depletion with reduced paracortical area was observed in the ARC and AIDS stage nodes. The maximum section area of the entire popliteal lymph node was expanded significantly in the AP nodes. The paracortical area expanded in the AP nodes and decreased in the ARC and AIDS stage nodes. The cell density in the paracortical area in the AP nodes did not show a significant increase, while there was a significant reduction in the ARC and AIDS stage nodes. The lymph node CD4/CD8 ratio in the AP and ARC stages significantly decreased as compared with that of uninfected control cats, but conversion of the ratio was not seen. The estimated total numbers of CD4 + and CD8 + cells in the maximum section were increased in the AP stage but significantly decreased in the ARC and AIDS stages. Our study indicated that the lymphocyte depletion in the terminal ARC and AIDS stages of FIV infection was associated with both CD4 + cells and CD8 + cells. Findings obtained in this study might provide useful information for studying the pathophysiology of FIV infection. -KEY WORDS: CD4, CD8, feline immunodeficiency virus, lymph node.

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Suppression of lymphocyte blastogenesis to mitogens in cats experimentally infected with feline immunodeficiency virus

Cited by 43 publications

References 11 publications

Puma Lentivirus Is Controlled in Domestic Cats after Mucosal Exposure in the Absence of Conventional Indicators of Immunity

Puma Lentivirus Is Controlled in Domestic Cats after Mucosal Exposure in the Absence of Conventional Indicators of Immunity

Comparative study of the cell tropism of feline immunodeficiency virus isolates of subtypes A, B and D classified on the basis of the env gene V3-V5 sequence

Alteration of T-Cell Subsets in the Lymph Nodes from Cats Infected with Feline Immunodeficiency Virus

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