Suppression of lordosis in the hormone-primed female hamster by electrical stimulation of the septal area

Zasorin, N.L.; Malsbury, Charles W.; Pfaff, Donald W.

doi:10.1016/0031-9384(75)90187-0

Cited by 59 publications

(15 citation statements)

References 8 publications

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“…MPO plays a gender-dependent role in reproductive behavior. In females, bilateral lesions of the MPO facilitate the occurrence of lordosis (Powers and Valenstein, 1972;Nance et al, 1977;Rodriguez-Sierra and Terasawa, 1979;Lisk and MacGregor, 1982;Hoshina et al, 1994); chemical or electrical stimulation of MPO suppresses it (Moss et al, 1974;Zasorin et al, 1975;Pfaff and Sakuma, 1979;Takeo et al, 1993). By contrast, in males MPO lesions completely abolish mounting, intromission, and ejaculation, whereas stimulation of this region induces copulation (Heimer and Larrson, 1966;Lisk, 1966;Malsbury et al, 1981;Hansen et al, 1982;Arendash and Gorski, 1983;Edwards and Einhorn, 1986).…”

Section: Reproductivementioning

confidence: 99%

Medial preoptic area afferents to periaqueductal gray medullo-output neurons: a combined Fos and tract tracing study

et al. 1996

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We have shown recently that the medial preoptic area (MPO) robustly innervates discrete columns along the rostrocaudal axis of the midbrain periaqueductal gray (PAG). However, the location of PAG neurons responsive to MPO activation is not known. Anterograde tract tracing was used in combination with Fos immunohistochemistry to characterize the MPO -+ PAG pathway anatomically and ,functionally within the same animal. Focal electrical or chemical stimulation of MPO in anesthetized rats induced extensive Fos expression within the PAG compared with sham controls. Fos-positive neurons were organized as 2-3 longitudinal columns. The organization and location of these columns overlapped remarkably well with the distribution of fibers and terminals in PAG labeled by Phaseolus vulgaris leucoagglutinin (PHA-L) injected into the same MPO stimulation site. This indicates that MPO inputs may terminate on the soma or proximal dendrites of neurons exhibiting elevated Fos. A second series of experiments investigated whether MPO stimulation excited PAG neurons with descending projections to the medulla. Retrograde labeling of PAG neurons projecting to the medial and lateral regions of the rostroventral medulla (RVM) was combined with MPO-induced Fos expression. The results showed that a substantial population (3743%)of Fos-positive PAG neurons projected to the ventral medulla. This indicates that MPO stimulation engages PAG-medullary output neurons. Taken together, these results suggest that the MPO + PAG + RVM projection constitutes a functional pathway. This circuit may coordinately regulate neuroendocrine, motor, and autonomic adjustments necessary for the elaboration of sexual behaviors.Key words: reproduction; antinociception; cardiovascular regulation; brainstem; sexual behavior; immunohistochemistryThe medial preoptic area (h/[PO) is a sexually dimorphic structure Simerly et al., 1984;Bloch and Gorski, 1988) that plays a pivotal role in sexual behavior and neuroendocrine function (Lisk, 1966;Powers and Valenstein, 1972;Pfaff and Sakuma, 1979;Hansen et al., 1982;Arendash and Gorski, 1983;Kalra and Kalra, 1983;Docke et al., 1984;Sachs and Meisel, 1988;Simerly et al., 1990;DonCarlos et al., 1991;Takeo et al., 1993;Hoshina et al., 1994). We recently reported that MPO robustly innervates the midbrain periaqueductal gray (PAG) (Rizvi et al., 1992) and terminates in discrete, longitudinally organized columns running through the rostrocaudal axis of PAG.PAG plays a key role in antinociception (Reynolds, 1969;Liebeskind et al., 1973;Oliveras et al., 1974;Behbehani and Fields, 1979; Lovick, 3985;Morgan and Liebeskind, 1987;Reichling et al., 1988;Lovick, 1990), cardiovascular control (Lovick, 1985;Carrive et al., 1987;Carrive et al., 1988;Carrive et al., 1989a;Lovick, 1990;Verberne and Guyenet, 1992;Murphy et al., 1994a;Murphy et al., 1995), and many of the same neuroendocrine and reproductive functions as MPO (Pfaff and SchwartzGiblin, 1988;Ogawa et al., 1991;Shipley et al., 1995). PAG neurons involved in these functions also are ...

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Section: Reproductivementioning

confidence: 99%

Medial preoptic area afferents to periaqueductal gray medullo-output neurons: a combined Fos and tract tracing study

et al. 1996

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“…However, injecting vasopressin di rectly into the lateral septum did not affect male sexual behavior (Koolhaas et al 1991). Lesion and stimulation studies have implicated areas innervated by the sexually dimorphic vasopressin fibers in female sexual behavior as well (Nance et al 1974;Zasorin et al 1975). In fact, intraventricular injections of vasopressin stimulate female sexual behavior, and similar injections of vasopressin antagonist inhibit it (Sodersten et al 1985).…”

Section: Sexual Behaviormentioning

confidence: 99%

Studying neurotransmitter systems to understand the development and function of sex differences in the brain: the case of vasopressin

Vries¹,

Geert²

1995

Neurobiological Effects of Sex Steroid Hormones

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“…Unilateral implantation of estrogen into the right side of the septum was also effective to enhance lordosis, and the degree of lordosis was almost the same as in the case of bilateral implantation in the present experiment. Unilateral electrical stimulation in the lateral septum has been reported to shorten the duration of lordosis in hamsters [25]. In addition, unilateral estrogen implantation in the VMN had been reported to potentiate lordosis [9].…”

Section: Discussionmentioning

confidence: 99%

“…The LS lesion or cut decreases the dose of estrogen which is needed to induce lordosis and soliciting behavior in ovariectomized rats [12, 13]. Electrical stimulation in this area shortens lordosis duration in female hamsters [14]. In addition, since lordosis behavior is enhanced by destruction of the LS in male rats [15, 16], the strength of the inhibitory influence in the LS is thought to produce a sex difference in neural mechanisms for the regulation of female sexual behavior [11].…”

Section: Introductionmentioning

confidence: 99%

Effect of Direct Application of Estrogen Aimed at Lateral Septum or Dorsal Raphe Nucleus on Lordosis Behavior: Regional and Sexual Differences in Rats

Satou

Yamanouchi²

1999

Neuroendocrinology

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The role of estrogen in lordosis-inhibiting systems in the lateral septum or the dorsal raphe nucleus was investigated in female and male rats. Ovariectomized rats received implantation of 22-gauge guide cannulae to the bilateral or right side of the lateral septum (LS and rLS, respectively), the dorsal raphe nucleus (DRN) or bilateral cortex (CX). In castrated male rats, bilateral implantations of the cannulae to the LS were carried out (mLS). Three behavioral tests in total were performed at 2-week intervals. In the first test, all animals were subcutaneously injected with 1.5 µg/kg estradiol benzoate (EB). Forty-four hours after EB, 0.5 mg progesterone (P) was injected and a behavioral test was started 4 h after P. These hormonal regimes were used in all tests. In the second test, 2 h before EB injection, 27-gauge cannulae filled with estradiol (E₂) were inserted into the DRN, LS or CX through the guide cannulae and were kept there for 4 h. In the third test, cholesterol was implanted instead of E₂ into these areas. In the first test, most females showed low levels of lordosis quotient (LQ) and most males showed no lordosis. In the second test, mean LQs in the LS or rLS groups of females increased but not in the DRN and CX groups. In the mLS group no increase of LQ was observed. When cholesterol was implanted in the third test, mean LQs in all groups were as low as in the first test. These results suggest the possibility that estrogen releases the inhibition when it acts on the LS, but not on the DRN female rats. On the other hand, inhibition in the male LS may not be released by the direct action of estrogen.

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Suppression of lordosis in the hormone-primed female hamster by electrical stimulation of the septal area

Cited by 59 publications

References 8 publications

Medial preoptic area afferents to periaqueductal gray medullo-output neurons: a combined Fos and tract tracing study

Medial preoptic area afferents to periaqueductal gray medullo-output neurons: a combined Fos and tract tracing study

Studying neurotransmitter systems to understand the development and function of sex differences in the brain: the case of vasopressin

Effect of Direct Application of Estrogen Aimed at Lateral Septum or Dorsal Raphe Nucleus on Lordosis Behavior: Regional and Sexual Differences in Rats

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