Suppression of knee joint osteoarthritis induced secondary to type 2 diabetes mellitus in rats by resveratrol: role of glycated haemoglobin and hyperlipidaemia and biomarkers of inflammation and oxidative stress

Ebrahim, Hasnaa Ali; Alzamil, Norah M; Haidara, Mohamed A; Kamar, Samaa S; Dawood, Amal F

doi:10.1080/13813455.2020.1771378

Cited by 11 publications

(6 citation statements)

References 25 publications

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“…8,14,17,85,86 The I-ERS mouse model provides an important model system in which to obtain a more complete understanding of primary OA. The finding that resveratrol prevents ER stresseinduced joint degeneration in the I-ERS mouse along with the observation that resveratrol prevents OA induced in animal models by type II diabetes, 70 high-fat diet, 53,54 monosodium iodoacetate, 67 and surgery 55 indicates that resveratrol may be able to prevent and/or ameliorate primary and PTOA.…”

Section: Discussionmentioning

confidence: 93%

Primary Osteoarthritis Early Joint Degeneration Induced by Endoplasmic Reticulum Stress Is Mitigated by Resveratrol

Hecht

Veerisetty

et al. 2021

The American Journal of Pathology

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Section: Discussionmentioning

confidence: 93%

Primary Osteoarthritis Early Joint Degeneration Induced by Endoplasmic Reticulum Stress Is Mitigated by Resveratrol

Hecht

Veerisetty

et al. 2021

The American Journal of Pathology

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“…Such biomarkers as intracellular GSH-Px, GSH, CAT, SOD, and MDA are commonly used to assess the level of OS in cells or tissues [ 14 ]. Therefore, to verify whether PCE has antioxidant properties that prevent OA-induced HepG2 cells from hyperlipidemia, the effects of PCE on MDA and GSH production and ROS scavenging enzyme (GSH-Px, CAT, and SOD) activities in OA-induced HepG2 cell influences were investigated.…”

Section: Resultsmentioning

confidence: 99%

Polygonum cuspidatum Extract Exerts Antihyperlipidemic Effects by Regulation of PI3K/AKT/FOXO3 Signaling Pathway

Tao

Zhang

Liu

et al. 2021

Oxidative Medicine and Cellular Longevity

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Polygonum cuspidatum (PC) has been reported to exert a potent antihyperlipidemic effect. However, its mechanisms of action and active ingredients remain elusive and require further research. In this study, we first conducted in vivo experiments to validate that Polygonum cuspidatum extract (PCE) could ameliorate the blood lipid level in hyperlipidemia model rats. Then, ultrahigh performance liquid chromatography coupled with Q-Exactive MS/MS (UPLC-QE-MS/MS) was applied to verify its 12 main active ingredients. The pharmacophore matching model was employed to predict the target point of the active ingredient, and 27 overlapping genes were identified via database and literature mining. String online database and Cytoscape software were utilized to construct a Protein-Protein Interaction (PPI) network, followed by function annotation analysis and pathway enrichment analysis. The results showed that the PI3K/AKT signaling pathway and its downstream FOXO3/ERα factors were significantly enriched. Furthermore, in vitro experiments were performed to determine the lipid content and oxidative stress (OS) indicators in OA-induced HepG2 cells, and immunofluorescence and western blotting analysis were carried out to analyze the effects of PCE on related proteins. Our experimental results show that the mechanism of antihyperlipidemic action of PCE is related to the activation of the PI3K/AKT signaling pathway and its downstream FOXO3/ERα factors, and polydatin and resveratrol are the main active ingredients in PCE that exert antihyperlipidemic effects.

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“…Besides, recent studies have shown that advanced glycosylation end products (AGEs) are also engaged in KOA inflammation, and that AGEs binding to the receptor for AGEs (RAGE) has been shown to upregulate inflammatory markers to exacerbate cartilage inflammatory responses ( Yang et al, 2011 ; Vistoli et al, 2013 ). Several studies have found that RES treatment for 12 weeks in a diabetes mellitus type 2 (T2DM)-induced KOA rat model significantly improved the inflammatory response of cartilage in the high-glucose state as well as abnormal blood glucose levels ( Ebrahim et al, 2020 ; El-Bidawy et al, 2021 ). Besides, RES and curcumin supplementation prevented AGEs-induced cartilage inflammatory response by inhibiting AGEs accumulation, probably due to the unique chemical structure of RES and curcumin, both of which have p-hydroxyl groups in their structure that competitively inhibit the binding of AGEs to RAGE ( Mehta et al, 2021 ).…”

Section: Preclinical Studies About Res and Its Effects In Koamentioning

confidence: 99%

Protective Effect of Resveratrol on Knee Osteoarthritis and its Molecular Mechanisms: A Recent Review in Preclinical and Clinical Trials

Yang¹,

Sun²,

Zhang³

2022

Front. Pharmacol.

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Osteoarthritis (OA) is one of the progressing chronic joint associated with by many complex factors such as age, obesity, and trauma. Knee osteoarthritis (KOA) is the most common type of OA. KOA is characterized by articular cartilage destruction and degeneration, synovial inflammation, and abnormal subchondral bone changes. To date, no practical clinical approach has been able to modify the pathological progression of KOA. Drug therapy is limited to pain control and may lead to serious side effects when taken for a long time. Therefore, searching for safer and more reliable treatments has become necessary. Interestingly, more and more research has focused on natural products, and monomeric compounds derived from natural products have received much attention as drug candidates for KOA treatment. Resveratrol (RES), a natural phenolic compound, has various pharmacological and biological activities, including anti-cancer, anti-apoptotic, and anti-decay. Recently, studies on the effects of RES on maintaining the normal homeostasis of chondrocytes in KOA have received increasing attention, which seems to be attributed to the multi-targeted effects of RES on chondrocyte function. This review summarizes preclinical trials, clinical trials, and emerging tissue engineering studies of RES for KOA and discusses the specific mechanisms by which RES alleviates KOA. A better understanding of the pharmacological role of RES in KOA could provide clinical implications for intervention in the development of KOA.

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Suppression of knee joint osteoarthritis induced secondary to type 2 diabetes mellitus in rats by resveratrol: role of glycated haemoglobin and hyperlipidaemia and biomarkers of inflammation and oxidative stress

Cited by 11 publications

References 25 publications

Primary Osteoarthritis Early Joint Degeneration Induced by Endoplasmic Reticulum Stress Is Mitigated by Resveratrol

Primary Osteoarthritis Early Joint Degeneration Induced by Endoplasmic Reticulum Stress Is Mitigated by Resveratrol

Polygonum cuspidatum Extract Exerts Antihyperlipidemic Effects by Regulation of PI3K/AKT/FOXO3 Signaling Pathway

Protective Effect of Resveratrol on Knee Osteoarthritis and its Molecular Mechanisms: A Recent Review in Preclinical and Clinical Trials

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