Suppression of Immune Responses by CD8 Cells. II. Qa-1 on Activated B Cells Stimulates CD8 Cell Suppression of T Helper 2 Responses

Abstract

We have investigated the role of MHC class I products and CD8 T cells in regulating Ab responses using β2-microglobulin deficient (β2m−/−) mice. β2m−/− mice produced stronger IgM and IgG responses than did control β2m+/+ mice to both cellular and viral Ags. These Ab responses could be suppressed by infusion of activated B cells from β2m+/+ mice. Further investigation showed that the β2m-associated molecule on activated B cells that induced CD8 suppression was Qa-1 and that the Th2 component of CD4 cells was most affected by CD8-suppressive activity. Our findings suggest a novel pathway of Th inhibition in which B cell presentation of Qa-1-associated peptides stimulates CD8 suppressive activity.

CD8 T-cell subsets: heterogeneity, functions, and therapeutic potential

“…The suppressive functions of CD8 T cells, restricted to the nonclassical MHC class I molecule Qa-1, in humoral responses was discovered in β 2 m-knockout mice 134,136 . These suppressive CD8 + Tregs recognize the Qa-1 peptide and are characterized by their expression of CD122 and Ly49 molecules.…”