Suppression of immune complex-induced inflammation by the chemotactic factor inactivator.

Johnson, Kent J.; Anderson, Thomas P.; Ward, Peter A.

doi:10.1172/jci108717

Cited by 29 publications

(5 citation statements)

References 12 publications

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“…Our preliminary experiments involving mixing of supernate obtained 24 h after stimulation with that obtained from unstimulated monolayers at 24 h seem to support the last of these possibilities. The presence ofan inhibitor which modulates or suppresses the inflammatory response has been previously demonstrated by Ward and co-workers (29,30). We have not yet purified this inhibitor material from the 24-h supernate.…”

Section: Discussionmentioning

confidence: 81%

Alveolar macrophage-derived chemotactic factor: kinetics of in vitro production and partial characterization.

et al. 1980

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A B S T R A C T Alveolar macrophages are the initial phagocytic cells that encounter foreign material and particulates deposited in the terminal airways. We have examined a mechanism by which these cells, after phagocytic challenge, may control or amplify the inflammatory response in lung parenchyma. Normal human alveolar macrophages (AM) were studied from eight subjects. With in vitro culture, AM produced and released two substances into culture media which have potent chemoattractant activity for blood polymorphonuclear granulocytes(PMN) and negligible activity for mononuclear cells. Release of these factors is maximally stimulated by aggregated human immunoglobulin (Ig)G or zymosan particles; however, simple adhesion of the macrophages to plastic surfaces is also sufficient to stimulate release of these chemotactic substances.The larger substance (10,000 daltons) is immunologically distinct from C5a and interacts with a different PMN membrane receptor than that known to exist for formyl-methionyl-leucyl-phenylalanine. Its chemotactic activity is sensitive to the enzymatic effect of trypsin. Although producing a single elution peak on gelfiltration chromatography, electrofocusing in polyacrylamide gels yielded five peaks of radioactivity. Chemotactic activity was localized to a fraction with a pI = 5.0. The smaller molecular weight substance has been less well characterized. Thus, the human AM can produce at least two factors which attract PMN and this capability may augment the local inflammatory response in the lung.

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Section: Discussionmentioning

confidence: 81%

Alveolar macrophage-derived chemotactic factor: kinetics of in vitro production and partial characterization.

et al. 1980

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“…Chemotactic factor inactivators (CFI) [16] with specificity for chemotactic C5 fragments and bacterial chemotaxin have been identified [168], In vivo, CFI suppresses immune complex-in duced inflammation [107] and plasma levels of CFI rise rapidly during experimental in flammation [95,122]. Plasma also contains an acylhydrolase which inactivates platelet activating factor [20.…”

Section: Inactivation O F Chemotaxinsmentioning

confidence: 99%

Margination and Emigration of Leucocytes

Colditz¹

1985

Pathol Immunopathol Res

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“…For this reason, it seems relevant to analyze the conditions which modulate the influx of eosinophils at sites of inflam mation [6], Such studies may help to under stand the role of the eosinophils in various disease processes. Reports dealing with fac tors inhibiting eosinophil chemotaxis are rare as compared to studies of factors mod ulating the chemotactic activity of polymor phonuclear neutrophils (PMNs) in normal and pathologic conditions [10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Inactivation of Polymorphonuclear-Neutrophil Derived Eosinophil Chemotactic Factor by Human Serum

König¹,

Czarnetzki²

1978

Int Arch Allergy Immunol

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A low-molecular-weight eosinophil chemotactic factor (ECF) can be released from human neutrophils on stimulation with the calcium ionophore (A 23187) and during phagocytosis. The presence of human serum suppresses the chemotaxis of eosinophils by ECF significantly. The inhibition is not cell-directed but affects the ECF either by binding or enzymatic cleavage. The inactivators belong to a heterogeneous class of serum components in the 19s, 7s and 4s molecular weight range. Highly purified human IgM and IgA, but neither IgG nor human serum albumin inhibit eosinophil chemotaxis.

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Suppression of immune complex-induced inflammation by the chemotactic factor inactivator.

Cited by 29 publications

References 12 publications

Alveolar macrophage-derived chemotactic factor: kinetics of in vitro production and partial characterization.

Alveolar macrophage-derived chemotactic factor: kinetics of in vitro production and partial characterization.

Margination and Emigration of Leucocytes

Inactivation of Polymorphonuclear-Neutrophil Derived Eosinophil Chemotactic Factor by Human Serum

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