Abstract:Background:
Ethanol has been shown to increase oxidative stress, drug efflux transporter expression, and promote
HIV progression. Macrophages, which express drug efflux transporters, serve as an essential sanctuary site for HIV. The
antiretroviral drug lopinavir, a protease inhibitor, is a substrate of the drug efflux transporters P-glycoprotein and multi-drug
resistance-associated protein 1. The NF-κB signaling pathway is associated with inflammation and drug efflux transporter
expression.
Objective:
Exami… Show more
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