Suppression of heterologous immunity by Nematospiroides dubius antigens in vitro

Crawford, Cynda; Behnke, Jerzy M.; Pritchard, David

doi:10.1016/0020-7519(89)90018-0

Cited by 20 publications

(9 citation statements)

References 25 publications

(9 reference statements)

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“…Immunodepression is commonly observed in the initial stages of many parasitological diseases due to heiminths (Cross & Klesius, 1989;Crawford et al, 1989) and to endoparasitic insects (Baron & Weintraub, 1987). Our results suggest that such a phenomenon may also occur in the course of Dermatobia hominis infestations.…”

Section: Discussionsupporting

confidence: 55%

Rabbit antibody responses to experimental infestation with Dermatobia hominis

Lello

Boulard

1990

Medical Vet Entomology

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The three larval stages of Dermatobia hominis (Linnaeus) have been evaluated for their immunogenicity by ELISA and immunodiffusion (ID) using sera from experimentally infested rabbits. During a primary infestation, first instar D. hominis were found to cause most reaction and allowed the earliest diagnosis by ELISA. An inhibition of the antibody response against second and third instars was observed. The inhibition disappeared after departure of the larvae from the host. In experimentally immunized hosts the antibody response, following challenge, was highest against second and third instar antigens. Antibody remained elevated during the infestation but fell immediately after the larvae had left the host.

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Section: Discussionsupporting

confidence: 55%

Rabbit antibody responses to experimental infestation with Dermatobia hominis

Lello

Boulard

1990

Medical Vet Entomology

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“…Simultaneously, infection with H. polygyrus suppresses immune responses to a variety of heterologous antigens such as ovine erythrocytes (Shrimp, Crandall & Crandall 1975) and other nematode parasites (Behnke, Wakelin & Wilson 1978) normally expelled by what we now know to be Th2 mediated immune mechanisms. Suppressive activity is also demonstrable in vivo (Pritchard & Behnke 1985, Pritchard, Lawrence, Appleby, Gibb & Glover 1994, and in vitro using parasite extracts or excretory secretory (ES) products (Pritchard, Ali & Behnke 1984, Crawford, Behnke & Pritchard 1989. It is possible that such suppressive activity, which potentially has the ability to counteract mammalian Th2 driven immune responses (DeKruyff, Fang & Umetsu 1992), could be exploited for the development of novel therapeutics for Th2 mediated disease states e.g.…”

Section: Introductionmentioning

confidence: 99%

Heligmosomoides polygyrus immunomodulatory factor (IMF), targets T‐lymphocytes

Telford¹,

Dj²,

Appleby³

et al. 1998

Parasite Immunology

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Experiments were performed to investigate the immunological site of action of an immunomodulatory factor (IMF), isolated from the gastrointestinal nematode Heligmosomoides polygyrus. IMF inhibited antibody production in murine and human 'T-helper (Th-2) driven' immunoassays. The effects were mediated via T lymphocytes as T cell-depleted cultures failed to respond to IMF, a result confirmed by prepulsing discrete cell subsets with the immunomodulant. Although the molecular nature and mode of action of IMF has yet to be determined, it would appear to be a relatively small non-proteinaceous molecule. From this data, we suggest that H. polygyrus secretes a systemically-active IMF from the intestinal lumen, to down-regulate Th-2 cell development in order to promote its survival in a potentially immunologically hostile environment.

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“…Our studies with H. bakeri were terminated after more than 4 months, when egg production in WT, eotaxin −/− and STAT6 −/− mice was 50–100% of that seen in the first three weeks of infection (76), so we have yet to determine whether expulsion is affected by the deletion of these genes. H. bakeri is generally considered to be capable of inducing strong immunosuppression (134–136) and so deletion of eotaxin or STAT6 may have little additional impact. As a parasite largely restricted to the gut, it is also unlikely to be exposed to the same array of mechanisms that protect against N. brasiliensis and S. ratti .…”

Section: Heligmosomoides Bakerimentioning

confidence: 99%

Murine nematode immunology in Australasia

Dent

2010

Parasite Immunology

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A relatively small number of laboratories in Australia and New Zealand have consistently published on murine models of nematode immunology, and the parasite species principally used are Heligmosomoides bakeri (previously Heligmosomoides polygyrus), Strongyloides ratti, Nippostrongylus brasiliensis and Toxocara canis. These research groups have made significant contributions to both fundamental immunology and more specialized issues in host-parasite relationships. Topics addressed include immune regulation, including the expression and control of Type 2 cytokines and the responses induced, innate and adaptive host-protective mechanisms, antigen expression and immune evasion strategies utilized by parasitic helminths. This review addresses the last 30 years of research and identifies areas in which major progress can be made, given appropriate resources.

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Suppression of heterologous immunity by Nematospiroides dubius antigens in vitro

Abstract: populations with anti-thy 1.2 plus complement did not impair suppressor activity, and it was concluded that cells expressing the T-cell phenotype were not involved.

Cited by 20 publications

References 25 publications

Rabbit antibody responses to experimental infestation with Dermatobia hominis

Rabbit antibody responses to experimental infestation with Dermatobia hominis

Heligmosomoides polygyrus immunomodulatory factor (IMF), targets T‐lymphocytes

Murine nematode immunology in Australasia

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