Suppression of hepatocellular carcinoma by Ulva lactuca ulvan via gut microbiota and metabolite interactions

Qiu, Yinghui; Xu, Jingxiang; Liao, Wei; Wen, Yuxi; Jiang, Shiyue; Wen, Jiahui; Zhao, Chao

doi:10.1016/j.jare.2023.04.008

Cited by 7 publications

(2 citation statements)

References 56 publications

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“…In H22 hepatocellular carcinoma tumor-bearing mouse models, Ulva lactuca polysaccharide (UIP) extracted from green algae inhibits tumor growth by modulating gut microbiota and metabolite composition. Additionally, UIP has been found to suppress tumors in HepG2 and H22 cells by promoting ROS production [ 34 ]. Researchers, utilizing metabolomics, have demonstrated that Black fungus polysaccharide (BFP) inhibits tumor cell proliferation in H22 tumor-bearing mice by promoting DNA damage, weakening DNA damage repair, and inhibiting DNA synthesis [ 35 ].…”

Section: Nps With Therapeutic Activity For Liver Cancermentioning

confidence: 99%

“…This enhances the immune response in the host tumor microenvironment (TME), exerting anti-tumor effects [ 159 ]. Ulva lactuca polysaccharide (ULP) inhibits tumor growth in H22 tumor-bearing mice by modulating the composition and metabolites of the gut microbiota [ 34 ]. Additionally, the Grifola frondosa polysaccharide-protein complex extracted from maitake mushrooms altered the gut microbiota composition and abundance in H22 tumor-bearing mice.…”

Section: The Main Action Pathway and Potential Mechanism Of Natural C...mentioning

confidence: 99%

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Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms

Guo,

Yan,

Duan

et al. 2024

Nutrients

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Liver cancer ranks third globally among causes of cancer-related deaths, posing a significant public health challenge. However, current treatments are inadequate, prompting a growing demand for novel, safe, and effective therapies. Natural products (NPs) have emerged as promising candidates in drug development due to their diverse biological activities, low toxicity, and minimal side effects. This paper begins by reviewing existing treatment methods and drugs for liver cancer. It then summarizes the therapeutic effects of NPs sourced from various origins on liver cancer. Finally, we analyze the potential mechanisms of NPs in treating liver cancer, including inhibition of angiogenesis, migration, and invasion; regulation of the cell cycle; induction of apoptosis, autophagy, pyroptosis, and ferroptosis; influence on tumor metabolism; immune regulation; regulation of intestinal function; and regulation of key signaling pathways. This systematic review aims to provide a comprehensive overview of NPs research in liver cancer treatment, offering a foundation for further development and application in pharmaceuticals and functional foods.

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Section: Nps With Therapeutic Activity For Liver Cancermentioning

confidence: 99%

Section: The Main Action Pathway and Potential Mechanism Of Natural C...mentioning

confidence: 99%

Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms

Guo,

Yan,

Duan

et al. 2024

Nutrients

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Marine algae‐derived characterized bioactive compounds as therapy for cancer: A review on their classification, mechanism of action, and future perspectives

Liao,

Chen,

Shan

et al. 2024

Phytotherapy Research

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In 2022, there were around 20 million new cases and over 9.7 million cancer‐related deaths worldwide. An increasing number of metabolites with anticancer activity in algae had been isolated and identified, which were promising candidates for cancer therapy. Red algae are well‐known for the production of brominated metabolites, including terpenoids and phenols, which have the capacity to induce cell toxicity. Some non‐toxic biological macromolecules, including polysaccharides, are distinct secondary metabolites found in many algae, particularly green algae. They possess anticancer activities by inhibiting tumor angiogenesis, stimulating the immune response, and inducing apoptosis. However, the structure–activity relationship between these components and antitumor activity, as well as certain taxa within the algae, remains relatively unstudied. This work is based on the reports published from 2003 to 2024 in PubMed and ISI Web of Science databases. A comprehensive review of the characterized algal anticancer active compounds, together with their structure and mechanism of action was performed. Also, their structure–activity relationship was preliminarily summarized to better assess their potential properties as a natural, safe bioactive product to be used as an alternative for the treatment of cancers, leading to new opportunities for drug discovery.

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Algal carbohydrates: Sources, biosynthetic pathway, production, and applications

Sarkar,

Bandyopadhyay,

Gopikrishna

et al. 2024

Bioresource Technology

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Suppression of hepatocellular carcinoma by Ulva lactuca ulvan via gut microbiota and metabolite interactions

Cited by 7 publications

References 56 publications

Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms

Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms

Marine algae‐derived characterized bioactive compounds as therapy for cancer: A review on their classification, mechanism of action, and future perspectives

Algal carbohydrates: Sources, biosynthetic pathway, production, and applications

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