Suppression of hepatitis C virus RNA by interferon-α

Kanai, Koichi; Iwata, Koichiro; Nakao, Kuniaki; Kako, Makoto; Okamoto, Hiroaki

doi:10.1016/0140-6736(90)91768-6

Cited by 70 publications

(15 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effective doses of IFN-a-2a in the present study were similar to those used clinically in patients with hepatitis (Kanai et al, 1990). Because DOI-induced WDS are mediated by 5-HT2 receptor stimulation (Green et al, 1983) and are regarded as reflecting the functions of 5-HT2 receptor-mediated signaling (Kuroda et al, 1992), our results suggest that IFN-ct-2a may block this signaling pathway.…”

Section: Discussionmentioning

confidence: 50%

Effect of interferon-? on DOI-induced wet-dog shakes in rats

Kugaya

Kagaya

Uchitomi

et al. 1996

J. Neural Transmission

View full text Add to dashboard Cite

Summary. Acute (1 h) intraperitoneal (ip) treatment with interferon (IFN)-~-2a (300IU/g) significantly inhibited wet-dog shakes (WDS) induced by (+_)-l-(2,5-dimethoxy-4-iodophenyl)-2 aminopropane (DOI; 0.5, 1.0mg/kg), which is mediated by serotonin (5-hydroxytryptamine; 5-HT)2 receptor in rats. IFNdid not affect spontaneous locomotion. The inhibition of DOI (0.5 mg/kg)-induced WDS by IFN-ct was dose (90-300IU/g)-and time (l-6h)-dependent, and was prevented by 30 min pretreatment with naltrexone (NLTX; 1.0 mg/kg, ip), an opioid receptor antagonist. Acute (lh) intracerebroventricular (icv) treatment with IFN-ot (1,500IU/rat) also inhibited DOI (0.5mg/kg)-induced WDS, and the effect was blocked by NLTX (50~tg/rat, icv). These results suggest that IFN-a may modulate 5-HT2 receptor-mediated behavior through opioid receptors in the central nervous system.

show abstract

Section: Discussionmentioning

confidence: 50%

Effect of interferon-? on DOI-induced wet-dog shakes in rats

Kugaya

Kagaya

Uchitomi

et al. 1996

J. Neural Transmission

View full text Add to dashboard Cite

show abstract

“…1 IFN treatment is effective for patients with chronic hepatitis C, reducing ALT levels, improving histological activity, 10,11 and eliminating HCV-RNA. [12][13][14][15] However, the effectiveness of IFN therapy for patients with normal ALT remains poorly understood. Few studies have compared patients with elevated ALT levels and matched patients with normal ALT levels with respect to assessing sustained virological response rates.…”

Section: Introductionmentioning

confidence: 99%

Interferon monotherapy for patients with chronic hepatitis C and normal serum aminotransferase levels at commencement of treatment

et al. 2004

View full text Add to dashboard Cite

show abstract

“…Interferon has been shown to be effective for chronic hepatitis type C [25], and the effect proved to depend greatly on the HCV subtype [22,26,27]. This fact might suggest that certain subtypes have benign characters in the natural course of hepatitis, which in turn cause HCC less frequently than the other subtypes of HCV.…”

Section: Introductionmentioning

confidence: 99%

Influence of Hepatitis C Virus Subtype on Hepatocellular Carcinogenesis: A Multivariate Analysis of a Retrospective Cohort of 593 Patients with Cirrhosis

Ikeda¹,

Kobayashi²,

Someya³

et al. 2002

Intervirology

View full text Add to dashboard Cite

Objective: The influence of hepatitis C virus (HCV) subtypes on hepatocellular carcinogenesis was prospectively investigated. Methods: A total of 593 patients with HCV-related cirrhosis were recruited and their HCV subtype was determined. Results: The carcinogenesis rates in the patients with HCV group 1 (genotype 1a +1b, n = 442) and group 2 (genotype 2a +2b, n = 136) were 32.0 and 26.6% at the end of the 5th year, 57.4 and 48.1% at the end of the 10th year and 71.8 and 71.0% at the end of the 15th year, respectively (p = 0.10). As to those patients without a history of regular drinking (i.e. less than 200 kg on a pure alcohol basis), the carcinogenesis rates in group 1 (n = 277) and group 2 (n = 90) were 30.8 and 16.3% at the end of the 5th year, 52.8 and 34.4% at the end of the 10th year and 70.6 and 67.1% at the end of the 15th year, respectively (p = 0.025). Although HCV subtype did not influence carcinogenesis in patients with a drinking history of 200 kg or more (p = 0.62), it significantly affected the carcinogenesis rate in patients without a history of regular drinking. Multivariate analysis showed that HCV subtype group 1 significantly increased the carcinogenesis in the group without a history of regular drinking after adjustment for age and gender (hazard ratio = 2.57, p = 0.0085). Conclusion: The interaction between HCV subtype and drinking history should be considered in the prediction of carcinogenesis using a multiplicative proportional hazard model.

show abstract

Suppression of hepatitis C virus RNA by interferon-α

Cited by 70 publications

References 3 publications

Effect of interferon-? on DOI-induced wet-dog shakes in rats

Effect of interferon-? on DOI-induced wet-dog shakes in rats

Interferon monotherapy for patients with chronic hepatitis C and normal serum aminotransferase levels at commencement of treatment

Influence of Hepatitis C Virus Subtype on Hepatocellular Carcinogenesis: A Multivariate Analysis of a Retrospective Cohort of 593 Patients with Cirrhosis

Contact Info

Product

Resources

About