Abstract:BACKGROUND:
PAR1 (protease-activated receptor-1) contributes to acute thrombosis, but it is not clear whether the receptor is involved in deleterious inflammatory and profibrotic processes in heart failure. Here, we employ the pepducin technology to determine the effects of targeting PAR1 in a mouse heart failure with reduced ejection fraction model.
METHODS:
After undergoing transverse aortic constriction pressure overload or sham surgery, C57BL/6J mic… Show more
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