Suppression of Experimental Tractional Retinal Detachment by Low-Dose Radiation Therapy

Meredith, Travis A.; Ficker, Linda; Stevens, Rosalind; Olkowski, Zbigniew L.; Anderson, Mark T.; Hartmann, Janet; Crocker, Ian

doi:10.1001/archopht.1988.01060130735034

Cited by 14 publications

(6 citation statements)

References 24 publications

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“…Radiation (13)(14)(15), hyperthermia (1 6), and sustained drug-delivery systems with the use of microspheres (1 7-1 8) or liposomes ( 19-2 1) have been investigated for the treatment of PVR. Effective adjunctive therapy to refined surgical treatment has not been established clinically.…”

Section: Introductionmentioning

confidence: 44%

Implantable biodegradable polymeric device in the treatment of experimental proliferative vitreoretinopathy

Hashizoe

Ogura

Takanashi

et al. 1995

Current Eye Research

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We investigated the use of a scleral plug of biodegradable polymer implanted at the pars plana to create a controlled drug-delivery system in the vitreous. We evaluated the efficacy of a plug containing doxorubicin hydrochloride to treat experimental proliferative vitreoretinopathy (PVR) in pigmented rabbits. An implantable device on the sclera, which imitates a scleral plug, containing 1% doxorubicin, was prepared with poly(lactic acid) (molecular weight, 20,000). The release of doxorubicin in phosphate-buffered saline was evaluated by spectro-photometry. After pars plana vitrectomy and plug implantation, concentrations of doxorubicin in the vitreous humor of the rabbits were measured by high performance liquid chromatography. The release profiles were evaluated during 5 weeks in vitro and 4 weeks in vivo. Cultured homologous fibroblasts were injected into the vitreous space to induce experimental PVR after gas compression of the vitreous. The scleral plugs were implanted at the pars plana in treatment animals (n = 11). Control rabbits (n = 11) were followed up without implantation after PVR induction. All eyes of the control group developed tractional retinal detachment at day 28, while the incidence of retinal detachment was decreased to 64% in the treated eyes. (P = 0.002). The implantation of the scleral plug effectively inhibited intravitreous proliferation of fibroblasts. This study demonstrated that the scleral plug of biodegradable polymers may have potential as a treatment modality for PVR.

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Section: Introductionmentioning

confidence: 44%

Implantable biodegradable polymeric device in the treatment of experimental proliferative vitreoretinopathy

Hashizoe

Ogura

Takanashi

et al. 1995

Current Eye Research

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“…Our results indicate that the proliferation is delayed by radiation therapy the first 2 weeks, which is in agreement with the results observed by Meredith et al (1988). This study also demonstrates that the therapeutic range of fkactionized radiation therapy is limited, especially in the presence of PVR cells with different aging and activity.…”

Section: Discussionmentioning

confidence: 42%

Experimental perforating injury with high energy electrons to inhibit intraocular proliferation

Velikay¹,

Binder²,

Stolba³

et al. 1994

Acta Ophthalmologica

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Since 1980, the fibroblast model creating experimental proliferative vitreoretinopathy has been used to evaluate the antiproliferative effect of various drugs. In previous studies radiation therapy was found to reduce effectively intraocular proliferation in this model. We therefore investigated the effect of high energy electrons in a standard perforating injury model creating a traumatic proliferative vitreoretinopathy. In 36 eyes we performed a 8 mm pars plana incision and injected 0.4 ml of 80% fibronectin solution intravitreally. Ten rabbits (20 eyes) received radiation therapy with a Betatron accelerator in a total dosage of 3000 cGy to each eye divided into 10 single fractions starting on the first post-operative day. Maximum concentration of the dose was focused to the posterior vitreous. The other 9 rabbits, 18 eyes, served as control. In our perforating injury model we observed a reduction of retinal detachment rate of 72% in the controls to 55% in the treated group. The effect of radiation therapy with high energy electrons and total dosage of 3000 cGy was not statistically significant in experimental traumatic proliferative vitreoretinopathy.

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“…Radiation [23], hyperthermia [40], and a variety of drugs have been investigated for their utility in treating PVR [6,16,32,33]. However, no effective adjunctive therapy to refine surgical treatment has been established clinically.…”

Section: Introductionmentioning

confidence: 40%

Sustained release of cis-hydroxyproline in the treatment of experimental proliferative vitreoretinopathy in rabbits

Yasukawa¹,

Kimura

Tabata

et al. 2002

Graefe's Arch Clin Exp Ophthalmol

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Suppression of Experimental Tractional Retinal Detachment by Low-Dose Radiation Therapy

Cited by 14 publications

References 24 publications

Implantable biodegradable polymeric device in the treatment of experimental proliferative vitreoretinopathy

Implantable biodegradable polymeric device in the treatment of experimental proliferative vitreoretinopathy

Experimental perforating injury with high energy electrons to inhibit intraocular proliferation

Sustained release of cis-hydroxyproline in the treatment of experimental proliferative vitreoretinopathy in rabbits

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