Suppression of copulatory behavior by intracerebroventricular infusion of antisense oligodeoxynucleotide of granulin in neonatal male rats

Suzuki, Masatoshi; Bannai, Makoto; Matsumuro, Mie; Furuhata, Yasufumi; Ikemura, Ryota; Kuranaga, Erina; Kaneda, Yasufumi; Nishihara, Masugi; Takahashi, Michio

doi:10.1016/s0031-9384(99)00241-3

Cited by 44 publications

(33 citation statements)

References 34 publications

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“…Progranulin was shown to be involved in different stages of embryonic development (48 -51) and in sexual differentiation of the rat brain via actions on the ventromedial hypothalamus (52)(53)(54), and it may be a trigger for rat copulatory behavior (55). Progranulin induced the proliferation of embryonic fibroblasts (R-cells) obtained from mice that lack functional insulin-like growth factor-1 receptor (IGF-1).…”

Section: Discussionmentioning

confidence: 99%

A Novel Hematopoietic Granulin Induces Proliferation of Goldfish (Carassius auratus L.) Macrophages

Hanington

Barreda

Belosevic

2006

Journal of Biological Chemistry

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Granulins are a group of highly conserved growth factors that have been described from a variety of organisms spanning the metazoa. In this study, goldfish granulin was one of the most commonly identified transcripts in the differential cross-screening of macrophage cDNA libraries and was preferentially expressed in proliferating macrophages. Unlike mammalian granulins, which possess 7.5 repeats of a characteristic signature of 12 cysteine residues, the goldfish granulin encoded a putative peptide possessing only 1.5 cysteine repeats. Northern blot and real-time PCR analyses indicated that goldfish granulin was expressed only in the hematopoietic tissues of the goldfish, specifically the kidney and spleen, and in activated peripheral blood mononuclear cells. We expressed granulin using a prokaryotic expression system and produced an affinitypurified rabbit anti-goldfish granulin IgG. Recombinant goldfish granulin induced a dose-dependent proliferative response of goldfish macrophages that was inversely related to the myeloid differentiation stage of the cells studied. The highest proliferative response was observed in macrophage progenitor cells and monocytes. This proliferative response of macrophages was abrogated by the addition of anti-granulin IgG. These results indicate that goldfish granulin is a growth factor that positively modulates cell proliferation at distinct junctures of macrophage differentiation.

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Section: Discussionmentioning

confidence: 99%

A Novel Hematopoietic Granulin Induces Proliferation of Goldfish (Carassius auratus L.) Macrophages

Hanington

Barreda

Belosevic

2006

Journal of Biological Chemistry

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“…GRN mRNA was identified as one of the transcripts that were most strongly up-regulated by androgens in neonatal mouse hypothalami and in a series of elegant experiments by Suzuki et al (77) it was shown that depletion of PGRN blunts many of the normal masculine reproductive behaviors, particularly ejaculation. (78,79) Abrogation of the GRN gene in male mice showed unusual levels of anxiety, which were attributed at least in part to decreased expression of the serotonin receptor 5HT1A. (79) These findings coupled with the expression of PGRN in many regions of the embryonic mouse brain (51) hint at yet further roles for PGRN in brain development.…”

Section: Progranulin and Neurodegenerative Diseasesmentioning

confidence: 99%

The granulin gene family: from cancer to dementia

2009

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The growth factor progranulin (PGRN) regulates cell division, survival, and migration. PGRN is an extracellular glycoprotein bearing multiple copies of the cysteine-rich granulin motif. With PGRN family members in plants and slime mold, it represents one of the most ancient of the extracellular regulatory proteins still extant in modern animals. PRGN has multiple biological roles. It contributes to the regulation of early embryogenesis, to adult tissue repair and inflammation. Elevated PGRN levels often occur in cancers, and PGRN immunotherapy inhibits the growth of hepatic cancer xenografts in mice. Recent studies have demonstrated roles for PGRN in neurobiology. An autosomal dominant mutation in GRN, the gene for PGRN, leads to neuronal atrophy in the frontal and temporal lobes, resulting in the disease frontotemporal lobar dementia. In this review we will discuss current knowledge of the multifaceted biology of PGRN.

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“…Progranulin is highly expressed in the hypothalami of newborn male rats and is induced in female neonatal hypothalami by treatment with androgens (Suzuki et al, 1998). Abrogating the production of hypothalamic progranulin leads to impaired sexual differentiation of the male hypothalamus (Suzuki et al, 2000). Progranulin expression is moderately elevated during epithelial-mesenchyme transition (Kiemer et al, 2001), a process of importance in both embryonic development and tumor progression.…”

Section: Introductionmentioning

confidence: 99%

“…Given that progranulin regulates proliferative homeostasis and is involved in early (Diaz-Cueto et al, 2000) and late development (Suzuki et al, 1998(Suzuki et al, , 2000, it is important to determine where and when the gene is expressed during development. Here, we have investigated the expression of the progranulin gene in the mouse embryo.…”

Section: Introductionmentioning

confidence: 99%

Progranulin (acrogranin/PC cell‐derived growth factor/granulin‐epithelin precursor) is expressed in the placenta, epidermis, microvasculature, and brain during murine development

Daniel

Daniels

et al. 2003

Developmental Dynamics

143

114

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The growth factor progranulin (acrogranin/PC-derived growth factor/granulin-epithelin precursor) promotes onset of blastocyst cavitation and is required for neonatal hypothalamic sexual differentiation. Little is known, however, of the range of developmental processes in which it is involved. We used in situ hybridization to investigate progranulin expression in murine embryos. Progranulin mRNA is expressed in maternal and embryonic components during early establishment of pregnancy. Abundant expression is observed in the early decidualizing uterine stroma and glands. In the embryo, the trophoblast giant cells at the interface of placental exchange sites (both choriovitelline and chorioallantoic placenta) show strong expression. The gastrulating epiblast and mesenchyme (intraembryonic and extraembryonic mesenchyme) all revealed activity. The allantois and yolk sac mesenchyme (site of early hemopoiesis) were positive, as were later phases of active vessel formation (pia mater of brain, epicardium of the heart). In the urogenital system, it was expressed in Sertoli cells and in kidney tubules. It was highly expressed in proliferating epidermal cells. During epidermal appendage formation, the early epithelial bud was positive, but the forming duct and differentiating adjacent mesenchyme was negative. It is widely distributed during central nervous system development and the peripheral nervous system (dorsal root ganglia and sympathetic ganglia). Based on the pattern of progranulin gene expression, we propose proliferative and developmental roles for progranulin in establishing pregnancy, during gastrulation, and during embryonic development of the epidermis, nervous system, blood vessel, formation, and spermatogenesis. Developmental Dynamics 227:593-599, 2003.

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Suppression of copulatory behavior by intracerebroventricular infusion of antisense oligodeoxynucleotide of granulin in neonatal male rats

Cited by 44 publications

References 34 publications

A Novel Hematopoietic Granulin Induces Proliferation of Goldfish (Carassius auratus L.) Macrophages

A Novel Hematopoietic Granulin Induces Proliferation of Goldfish (Carassius auratus L.) Macrophages

The granulin gene family: from cancer to dementia

Progranulin (acrogranin/PC cell‐derived growth factor/granulin‐epithelin precursor) is expressed in the placenta, epidermis, microvasculature, and brain during murine development

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