Suppression of c-myc expression and c-Myc function in response to sustained DNA damage in MCF-7 breast tumor cells33Abbreviations: ODC, ornithine decarboxylase; VM-26 (teniposide), 4′-demethylepipodophyllotoxin-4-(4,6-O-thenylidene-β-d-glucopyranoside); pRb, retinoblastoma protein; m-AMSA, amsacrine; TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; and FBS, fetal bovine serum.

MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies

“…Exposure of MCF-7 breast tumor cell line to DNA-damaging agents such as topoisomerase II inhibitors VM-26, m-AMSA, and doxorubicin, or ionizing radiation is capable of suppressing MYC mRNA [ 234 – 237 ]. Moreover, continuous treatment of MCF-7 with VM-26 suppresses both mRNA and protein levels of MYC, and its transcriptional activity in response to sustained DNA damage [ 238 ]. Treatment of MCF-7 cells with camptothecin at the concentrations, causing DNA damage results in MYC suppression, while in lower concentrations, this attenuation in MYC expression vanishes due to the absence of detectable DNA damage [ 239 ].…”

The centella asiatica juice effects on DNA damage, apoptosis and gene expression in hepatocellular carcinoma (HCC)

“…It was found that the Centella asiatica juice reduced c-myc gene in HepG2 cells. It seems that this condition was a response to sustain DNA damage in HepG2 cells during DNA fragmentation in apoptosis [30,31]. Down regulation of c-myc gene may affect apoptosis due to the following conditions; serum starvation, chemically induced and exposed to viruses [32,33].…”

G-quadruplex-guided cisplatin triggers multiple pathways in targeted chemotherapy and immunotherapy

“…3f-h), nally repressing the proliferation of tumor cells and tumor angiogenesis to achieve the goal of inhibiting tumor growth. 55,59 Effects of PyPDSplatins on gene transcription and G4 damage To investigate the effects of these three PyPDSplatins on gene expression patterns, we performed RNA sequencing (RNA-Seq) with MDA-MB-231 cells (Fig. S15-S22 †).…”

“…3f-h), finally repressing the proliferation of tumor cells and tumor angiogenesis to achieve the goal of inhibiting tumor growth. 55,59 Effects of PyPDSplatins on Gene Transcription and G4 Damage.…”