Suppression of bone marrow–derived microglia in the amygdala improves anxiety-like behavior induced by chronic partial sciatic nerve ligation in mice

Sawada, Atsushi; Niiyama, Yukitoshi; Ataka, Koji; Nagaishi, Kanna; Yamakage, Michiaki; Fujimiya, Mineko

doi:10.1016/j.pain.2014.05.031

Cited by 72 publications

(79 citation statements)

References 37 publications

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“…In a preclinical model of neuropathic pain, partial sciatic nerve ligation induced anxiety-like behavior and trafficking of BM-derived monocytes into the AMYG [69]. In this same study, administration of CCR2 and IL-1 receptor antagonist in the AMYG ablated monocyte trafficking [69]. Stress-induced trafficking of inflammatory monocytes exacerbates the inflammatory signaling in the CNS and influences behavior [7,22,42,65,69].…”

Section: Stress-induced Neuroendocrine Outflow Increases Release and mentioning

confidence: 72%

“…Chemokine receptor 2 (CCR2) and β-adrenergic signaling contributed significantly to the infiltration of BM-derived monocytes [68,69]. In a preclinical model of neuropathic pain, partial sciatic nerve ligation induced anxiety-like behavior and trafficking of BM-derived monocytes into the AMYG [69]. In this same study, administration of CCR2 and IL-1 receptor antagonist in the AMYG ablated monocyte trafficking [69].…”

Section: Stress-induced Neuroendocrine Outflow Increases Release and mentioning

confidence: 74%

“…In this same study, administration of CCR2 and IL-1 receptor antagonist in the AMYG ablated monocyte trafficking [69]. Stress-induced trafficking of inflammatory monocytes exacerbates the inflammatory signaling in the CNS and influences behavior [7,22,42,65,69]. For instance, in a clinical study of depression, patients who committed suicide had increased Iba-1 immunolabeling compared to controls, indicating the presence of vascular-associated macrophages in the brain [71].…”

Section: Stress-induced Neuroendocrine Outflow Increases Release and mentioning

confidence: 76%

“…BM-derived monocytes traffic and are recruited into inflamed tissue in models of trauma, neurological disease and infection [66,67]. Evidence also indicates that trafficking and recruitment of monocytes from the periphery into the brain occur after exposure to psychological stress [7,19,42,68,69], representing a mechanism by which the immune system communicates with the brain. Following 5 days of foot shock stress, BM-derived monocytes trafficked to the ventral HPC and demonstrated a ramified microglia-like morphological phenotype [70].…”

Section: Stress-induced Neuroendocrine Outflow Increases Release and mentioning

confidence: 99%

“…The stimulus of simply watching other mice receiving foot shock stress was enough to recruit monocytes to the brain parenchyma in another study using rodents [68]. Chemokine receptor 2 (CCR2) and β-adrenergic signaling contributed significantly to the infiltration of BM-derived monocytes [68,69]. In a preclinical model of neuropathic pain, partial sciatic nerve ligation induced anxiety-like behavior and trafficking of BM-derived monocytes into the AMYG [69].…”

Section: Stress-induced Neuroendocrine Outflow Increases Release and mentioning

confidence: 99%

See 4 more Smart Citations

Stress-Induced Microglia Activation and Monocyte Trafficking to the Brain Underlie the Development of Anxiety and Depression

Ramírez

Trías

Sheridan

2016

Inflammation-Associated Depression: Evidence, Mechanisms and Implications

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Psychosocial stress is capable of causing immune dysregulation and increased neuroinflammatory signaling by repeated activation of the neuroendocrine and autonomic systems that may contribute to the development of anxiety and depression. The stress model of repeated social defeat (RSD) recapitulates many of the stress-driven alterations in the neuroimmune system seen in humans experiencing repeated forms of stress and associated affective disorders. For example, RSD-induced neuronal and microglia activation corresponds with sympathetic outflow to the peripheral immune system and increased ability of bone marrow derived myeloid progenitor cells (MPC) to redistribute throughout the body, including to the central nervous system (CNS), reinforcing stress-associated behaviors. An overview of the neuroendocrine, immunological, and behavioral stress-induced responses will be reviewed in this chapter using RSD to illustrate the mechanisms leading to stress-related alterations in inflammation in both the periphery and CNS, and stress-related changes in behavioral responses.

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Section: Stress-induced Neuroendocrine Outflow Increases Release and mentioning

confidence: 72%

Section: Stress-induced Neuroendocrine Outflow Increases Release and mentioning

confidence: 74%

Section: Stress-induced Neuroendocrine Outflow Increases Release and mentioning

confidence: 76%

Section: Stress-induced Neuroendocrine Outflow Increases Release and mentioning

confidence: 99%

Section: Stress-induced Neuroendocrine Outflow Increases Release and mentioning

confidence: 99%

See 3 more Smart Citations

Stress-Induced Microglia Activation and Monocyte Trafficking to the Brain Underlie the Development of Anxiety and Depression

Ramírez

Trías

Sheridan

2016

Inflammation-Associated Depression: Evidence, Mechanisms and Implications

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In Vivo Imaging of Translocator Protein in Long-term Cannabis Users

et al. 2019

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IMPORTANCE Cannabis is the most commonly used illicit drug in the world. Cannabinoids have been shown to modulate immune responses; however, the association of cannabis with neuroimmune function has never been investigated in vivo in the human brain.OBJECTIVE To investigate neuroimmune activation or 18-kDa translocator protein (TSPO) levels in long-term cannabis users, and to evaluate the association of brain TSPO levels with behavioral measures and inflammatory blood biomarkers. DESIGN, SETTING, AND PARTICIPANTSThis cross-sectional study based in Toronto, Ontario, recruited individuals from January 1, 2015, to October 30, 2018. Participants included long-term cannabis users (n = 24) and non-cannabis-using controls (n = 27). Cannabis users were included if they had a positive urine drug screen for only cannabis and if they used cannabis at least 4 times per week for the past 12 months and/or met the criteria for cannabis use disorder. All participants underwent a positron emission tomography scan with [ 18 F]FEPPA, or fluorine F 18-labeled N-(2-(2-fluoroethoxy)benzyl)-N-(4-phenoxypyridin-3-yl) acetamide.MAIN OUTCOMES AND MEASURES Total distribution volume was quantified across regions of interest. Stress and anxiety as well as peripheral measures of inflammatory cytokines and C-reactive protein levels were also measured. RESULTSIn total, 24 long-term cannabis users (mean [SD] age, 23.1 [3.8] years; 15 men [63%]) and 27 non-cannabis-using controls (mean [SD] age, 23.6 [4.2] years; 18 women [67%]) were included and completed all study procedures. Compared with the controls, cannabis users had higher [ 18 F]FEPPA total distribution volume (main group effect: F 1,48 = 6.5 [P = .01]; ROI effect: F 1,200 = 28.4 [P < .001]; Cohen d = 0.6; 23.3% higher), with a more prominent implication for the cannabis use disorder subgroup (n = 15; main group effect: F 1,39 = 8.5 [P = .006]; ROI effect: F 1,164 = 19.3 [P < .001]; Cohen d = 0.8; 31.5% higher). Greater TSPO levels in the brain were associated with stress and anxiety and with higher circulating C-reactive protein levels in cannabis users. CONCLUSIONS AND RELEVANCEThe results of this study suggest that TSPO levels in cannabis users, particularly in those with cannabis use disorder, are higher than those in non-cannabis-using controls. The findings emphasize the need for more complementary preclinical systems for a better understanding of the role of cannabinoids and TSPO in neuroimmune signaling.

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Paeoniflorin attenuates postoperative pain by suppressing Matrix Metalloproteinase‐9/2 in mice

Fan

Zhu

et al. 2017

European Journal of Pain

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Suppression of bone marrow–derived microglia in the amygdala improves anxiety-like behavior induced by chronic partial sciatic nerve ligation in mice

Cited by 72 publications

References 37 publications

Stress-Induced Microglia Activation and Monocyte Trafficking to the Brain Underlie the Development of Anxiety and Depression

Stress-Induced Microglia Activation and Monocyte Trafficking to the Brain Underlie the Development of Anxiety and Depression

In Vivo Imaging of Translocator Protein in Long-term Cannabis Users

Paeoniflorin attenuates postoperative pain by suppressing Matrix Metalloproteinase‐9/2 in mice

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