Suppression of AQP7 is Crucial for Proliferation and Lipid Metabolism in ccRCC
Jun Zhao,
Rui Wang,
Jiacheng Jin
et al.
Abstract:Background: It is well-established that reprogramming of lipid metabolism is a feature of clear cell renal cell carcinoma (ccRCC), which also acts as a driving force in oncogenesis induced by hypoxia-inducible factors (HIFs) in ccRCC. Aquaporin 7 (AQP7), a channel facilitates glycerol to pass through the membrane and induces a decrease in triglycerides (TGs) and glycerol in adipocytes. However, whether AQP7 takes a part in the lipid metabolism and malignant behaviors of ccRCC is still unclear.
Methods: The pro… Show more
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