Suppression of Apoptosis in UV-Damaged Human Melanomacells by a Fermented Milk, Kefir

Nagira, Tsutomu; Narisawa, Junko; Teruya, Kiichiro; Kusumoto, Ken-Ichi; Katakura, Yoshinori; Barnes, David W.; Maru, Shun-ichi; Shirahata, Sanetaka

doi:10.1007/0-306-46875-1_93

Cited by 2 publications

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Kefiran of Kefir have scavenging effect on superoxide radicals thereby giving protection against UV damage of human melanoma HMV-1 cells (Nagira et al 1999). Matsuu et al (2003) stated that milk Kefir reduced X-ray-induced apoptosis in rat's colon.…”

Section: Protection Against Apoptosismentioning

confidence: 99%

“…In another study it was demonstrated that Kefir exhibited protection against apoptosis for colonic epithelial stem cells through termination of caspase-3 stimulation. Consumption of Kefir may reduce the adverse side effects of irradiation in malignant patients undergoing irradiation therapy (Nagira et al 1999;Matsuu et al 2003).…”

Section: Protection Against Apoptosismentioning

confidence: 99%

See 1 more Smart Citation

Kefir – a fermented milk product beneficial for gastrointestinal health

Mitra¹,

Ghosh²

2021

IJDS

View full text Add to dashboard Cite

Kefir is becoming increasingly popular as a result of new research into its health benefits. It is a fermented product which originated in the Caucasus Mountains of Russia. Kefir is produced by the action of bacteria and yeasts existing in symbiotic association in kefir grains. The composition of kefir varies according to the type of milk and the microbiological composition of culture types (kefir grain or commercial starter culture). Kefir's distinctive flavour is attributed by lactic acid, ethanol, carbon dioxide and other flavouring agents, such as acetaldehyde and acetoin. The microorganisms in kefir produce vitamins, degrade protein and hydrolyse lactose making it a highly nutritious and digestible product. Kefir has a long history of health benefits in Eastern European countries. In this review, manufacturing technologies, physicochemical properties, microbiological composition, therapeutic activities (viz. antimicrobial, anticarcinogenic, immunomodulatory, probiotic properties etc.) as well as other health benefits, like reducing cholesterol and improving lactose tolerance have been summarised.

show abstract

Section: Protection Against Apoptosismentioning

confidence: 99%

Section: Protection Against Apoptosismentioning

confidence: 99%

Kefir – a fermented milk product beneficial for gastrointestinal health

Mitra¹,

Ghosh²

2021

IJDS

View full text Add to dashboard Cite

show abstract

Cardioprotective role of long-term kefir and omega-3 fatty acid supplementation on myocardial apoptosis via oxidative stress-mediated lysosomal cathepsin release in isoproterenol-induced myocardial infarction rat model

Ünver Şeker,

Oğlakçı İlhan,

Söztutar

et al. 2024

Med Sci Discov

View full text Add to dashboard Cite

Objective: The antiapoptotic and antioxidative role of long-term kefir and omega-3 fatty acids and their relationship with cysteine proteases on isoproterenol (ISO) induced myocardial infarction (MI) experimental model was investigated in our study. Material and Methods: Fifty male Sprague-Dawley rats were evenly divided into five distinct groups (n=10): Control, MI, kefir +MI, omega-3+MI, and kefir+omega 3+MI groups. Kefir 10% (with drinking water) and omega-3 fatty acid (30 mg/day per 100g body weight into the standard chow) were administrated during 30 days. ISO was subcutaneously injected into the rats (100 mg/ kg b.w.) on the 29th and 30th days. Myocardial tissue and blood samples were taken 12 hours after the last ISO dose. Creatine kinase MB (CK-MB) activities were measured in serum samples. Caspase-3, superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO), DNA fragmentation, cathepsin B and L levels, were measured in myocardial tissue. Results: Serum CK-MB (p<0.05) and cardiac tissue MDA (p>0.05), NO (p<0.01), caspase 3 (p<0.01), DNA fragmentation (p<0.001), cathepsin B (p<0.05) and L (p<0.05) activities were increased and SOD (p<0.001) activities were decreased in MI group compared to control group. The preventive effects of long-term therapy with kefir and omega-3 fatty acids have been demonstrated on apoptosis, oxidative stress markers, and cysteine protease enzymes. Conclusion: Our results showed that long-term administration of kefir and omega-3 fatty acids might be effective in reducing myocardial apoptosis through oxidative stress-mediated release of cysteine proteases in myocardial infarction, especially in the kefir and combined therapy groups.

show abstract

Suppression of Apoptosis in UV-Damaged Human Melanomacells by a Fermented Milk, Kefir

Cited by 2 publications

References 4 publications

Kefir – a fermented milk product beneficial for gastrointestinal health

Kefir – a fermented milk product beneficial for gastrointestinal health

Cardioprotective role of long-term kefir and omega-3 fatty acid supplementation on myocardial apoptosis via oxidative stress-mediated lysosomal cathepsin release in isoproterenol-induced myocardial infarction rat model

Contact Info

Product

Resources

About