2023
DOI: 10.1016/j.cellimm.2023.104675
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Suppression of anti-drug antibody formation against coagulation factor VIII by oral delivery of anti-CD3 monoclonal antibody in hemophilia A mice

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Cited by 5 publications
(4 citation statements)
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“…In contrast, FoxP3 + LAP + dual positive cells represent an activated form of traditional FoxP3 + Treg (rather than a distinct subset) that acquired those gene expression characteristics of FoxP3 -LAP + cells that relate to TGF-b and ICOS expression. Both these suppressive cell types expressed surface LAP, supporting prior claims in the literature that TGFb complexed to LAP is sufficient to induce FoxP3 expression in a contact dependent manner (12,13,33,(58)(59)(60)(61).…”
Section: Lap + Foxp3and Foxp3 + Treg Have Distinct Gene Expression Pa...supporting
confidence: 79%
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“…In contrast, FoxP3 + LAP + dual positive cells represent an activated form of traditional FoxP3 + Treg (rather than a distinct subset) that acquired those gene expression characteristics of FoxP3 -LAP + cells that relate to TGF-b and ICOS expression. Both these suppressive cell types expressed surface LAP, supporting prior claims in the literature that TGFb complexed to LAP is sufficient to induce FoxP3 expression in a contact dependent manner (12,13,33,(58)(59)(60)(61).…”
Section: Lap + Foxp3and Foxp3 + Treg Have Distinct Gene Expression Pa...supporting
confidence: 79%
“…We compared T conv (FoxP3 -LAP -), FoxP3 + LAP -, FoxP3 + LAP + , FoxP3 -LAP + cells (n=4/group). The FoxP3 + LAP + population highly upregulated activation and co-inhibitory molecules such as CD69, CD44, CTLA-4, PD1, LAG3, ICOS, GARP, and NRP1, consistent with its role as an activated cell subset with superior suppressive function (12,33) (Figure 4A). This population also upregulated the transcription factors IRF4 and BATF, which initiates differentiation towards an effector Treg phenotype (51).…”
Section: Foxp3 + Lapand Foxp3 -Lap + Cells Exhibit Distinct Gene Sign...mentioning
confidence: 73%
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“…An alternative approach to mitigating anti-FVIII antibodies involves oral delivery of anti-CD3 monoclonal antibody. 73 This method has the potential to modulate systemic immune responses, resulting in a reduction of anti-FVIII antibody titers, all without the need for T cell depletion. Further enhancements are anticipated, especially regarding the establishment of FVIII tolerance.…”
Section: Discussionmentioning
confidence: 99%