Suppression of Acoustic Streaming in Shape-Optimized Channels

Bach, Jacob Søberg; Bruus, Henrik

doi:10.1103/physrevlett.124.214501

Cited by 37 publications

(14 citation statements)

References 43 publications

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“…[37] A possible route to suppress acoustic microstreaming is to develop shape-optimized chambers. [38] Furthermore, the method selectivity may benefit from patterned particles in the one-cell-per-trap configuration. [5,39] 3.3.…”

Section: Acoustic Microstreamingmentioning

confidence: 99%

3D‐Printed Acoustofluidic Devices for Raman Spectroscopy of Cells

Santos

Silva

et al. 2021

Adv Eng Mater

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Acoustofluidics technology can be used to trap live cells (and also micro/nanoparticles) in microenvironments suitable for cell assays. Herein, a cheap and easyto-fabricate device is proposed that works with Raman spectroscopy for biosensing applications. The device comprises a 3D-printed microchamber working as a halfwavelength acoustic resonator. By tuning the resonance frequency with a low voltage (%4 V), cells or particles are aggregated and levitated in seconds by the action of the acoustic radiation force. Based on finite element simulations, the radiation force field produced inside the device is described. In the cellular enrichment (aggregation) process, a metastable honeycomb lattice is formed mostly due to the cell-to-cell attraction caused by the secondary acoustic radiation force. Orderly and metastable levitating aggregates provide an excellent arrangement for Raman spectroscopy to investigate cells individually. Polystyrene particles are used for the device characterization and Raman acquisition process. Biosensing applications are showcased with live murine macrophages J774.A1, which are used in infection assay of leishmaniasis disease. The unique features of the device, e.g., simple fabrication process with cheap materials, simple operation, fast time response, and formation of metastable cellular aggregates; hold a noteworthy potential for applications in life sciences and biotechnology involving cell assays.

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Section: Acoustic Microstreamingmentioning

confidence: 99%

3D‐Printed Acoustofluidic Devices for Raman Spectroscopy of Cells

Santos

Silva

et al. 2021

Adv Eng Mater

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“…Examples are microparticle trapping in acoustic tweezers [39][40][41][42][43][44] and in disposable capillary tubes [28,45], nanoparticle by using seed particles [46][47][48], and short and long term trapping [49,50]. Trapping and the associated focusing has been created by various methods, including standing bulk [51,52], traveling bulk [53], and surface [38,54,55] acoustic waves. An important focus area in the field is the trapping and focusing of biological cells in general [50,[56][57][58] and of circulating tumor cells in particular [30,59,60], in some cases accomplished by tuning the acoustic properties of the suspension medium tune relative to those of the given cells [30,61].…”

Section: Cell Trapping By Higher-harmonic Membrane Modesmentioning

confidence: 99%

“…Given the relatively strong bulk-driven Eckart streaming in the membrane trap, it is not easy to reduce the critical radius from the above-mentioned value of a cr = 8.5 µm. Several of the methods proposed in the literature are for systems dominated by boundary-driven Rayleigh streaming [53,70,71]. Perhaps only the method of trapped large seed particles would be a way to trap smaller particles in the membrane trap [46].…”

Section: Steady Acoustic Streaming In the Trapmentioning

confidence: 99%

Numerical study of acoustic cell trapping above elastic membrane disks driven in higher-harmonic modes by thin-film transducers with patterned electrodes

Steckel¹,

Bruus²

2021

Preprint

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Excitations of MHz acoustic modes are studied numerically in 10-µm-thick silicon disk membranes with a radius of 100 and 500 µm actuated by an attached 1-µm-thick (AlSc)N thin-film transducer. It is shown how higher-harmonic membrane modes can be excited selectively and efficiently by appropriate patterning of the transducer electrodes. When filling the half-space above the membrane with a liquid, the higher-harmonic modes induce acoustic pressure fields in the liquid with interference patterns that result in the formation of a single, strong trapping region located 50 -100 µm above the membrane, where a single suspended cell can be trapped in all three spatial directions. The trapping strength depends on the acoustic contrast between the cell and the liquid, and as a specific example it is shown by numerical simulation that by using a 60% iodixanol solution, a cancer cell can be held in the trap.

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“…Consequently, the flow characteristics will vary near solid or soft surfaces such as biological cell membranes, bubble surfaces or fluid interfaces and as such can provide very different modes of steady fluid transport. Recent advances in microfluidics and ultrasonic technologies stimulated resurgent interest in these phenomena [1][2][3][4][5][6][7][8] .…”

Section: Introductionmentioning

confidence: 99%

Analytical solution for an acoustic boundary layer around an oscillating rigid sphere

2020

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Analytical solutions in fluid dynamics can be used to elucidate the physics of complex flows and to serve as test cases for numerical models. In this work, we present the analytical solution for the acoustic boundary layer that develops around a rigid sphere executing small amplitude harmonic rectilinear motion in a compressible fluid.The mathematical framework that describes the primary flow is identical to that of wave propagation in linearly elastic solids, the difference being the appearance of complex instead of real valued wave numbers. The solution reverts to well-known classical solutions in special limits: the potential flow solution in the thin boundary layer limit, the oscillatory flat plate solution in the limit of large sphere radius and the Stokes flow solutions in the incompressible limit of infinite sound speed. As a companion analytical result, the steady second order acoustic streaming flow is obtained. This streaming flow is driven by the Reynolds stress tensor that arises from the axisymmetric first order primary flow around such a rigid sphere. These results are obtained with a linearization of the non-linear Navier-Stokes equations valid for small amplitude oscillations of the sphere. The streaming flow obeys a timeaveraged Stokes equation with a body force given by the Nyborg model in which the above mentioned primary flow in a compressible Newtonian fluid is used to estimate the time-averaged body force. Numerical results are presented to explore different regimes of the complex transverse and longitudinal wave numbers that characterize the primary flow.

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Suppression of Acoustic Streaming in Shape-Optimized Channels

Cited by 37 publications

References 43 publications

3D‐Printed Acoustofluidic Devices for Raman Spectroscopy of Cells

3D‐Printed Acoustofluidic Devices for Raman Spectroscopy of Cells

Numerical study of acoustic cell trapping above elastic membrane disks driven in higher-harmonic modes by thin-film transducers with patterned electrodes

Analytical solution for an acoustic boundary layer around an oscillating rigid sphere

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