“…It is generally agreed that transmesothelial penetration by cancer cells occurs at the junctional region between adjacent cells. It has been reported that cancer cells induce morphological changes of mesothelial cells by releasing some unknown substances (Kimura et al, 1985;Uchiyama et al, 1992) and may damage the mesothelial cells by attachment onto the mesothelial surface (Kiyasu et al, 1981). In cultured endothelial cells, several substances, including thrombin (Laposata et al, 1983), active oxygen (Shasby et al, 1985), 12(S)-HETE (Tang et al, 1993), tumour necrosis factor, interferon-y, interleukin 1 (Molony and Armstrong, 1991), histamine (Carson et al, 1989) and tyrosine phosphatase inhibitor (Staddon et al, 1995), are confirmed to increase permeability.…”