Suppression and dissolution of amyloid aggregates using ionic liquids

Takekiyo, Takahiro; Yoshimura, Yukihiro

doi:10.1007/s12551-018-0421-8

Cited by 28 publications

(18 citation statements)

References 58 publications

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“…The possibilities include, but are not limited to, anti-bacterial properties, and the stabilization and storage of bio-molecules such as proteins, enzymes, and DNA. More impressively, the abilities of ILs to re-functionalize defective amyloid fibers, dissolve complex polysaccharides, and create pores in bio-membranes, among many others were reported [ 4 , 32 , 36 , 37 , 38 , 39 , 40 ]. These processes can yield merits such as selective bacterial killing, selective toxicity to cancerous cells, and application for transdermal systems, respectively.…”

Section: Properties Of Ilsmentioning

confidence: 99%

Ionic Liquids as Potential and Synergistic Permeation Enhancers for Transdermal Drug Delivery

et al. 2019

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Transdermal drug delivery systems (TDDS) show clear advantages over conventional routes of drug administration. Nonetheless, there are limitations to current TDDS which warrant further research to improve current TDD platforms. Spurred by the synthesis of novel biodegradable ionic liquids (ILs) and favorable cytotoxicity studies, ILs were shown to be a possible solution to overcome these challenges. Their favorable application in overcoming challenges ranging from synthesis, manufacture, and even therapeutic benefits were documented. In this review, said ILs are highlighted and their role in TDDS is reviewed in terms of (a) ILs as permeation enhancers (single agents or combined), (b) ILs in drug modification, and (c) ILs as active pharmaceutical ingredients. Furthermore, future combination of ILs with other chemical permeation enhancers (CPEs) is proposed and discussed.

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Section: Properties Of Ilsmentioning

confidence: 99%

Ionic Liquids as Potential and Synergistic Permeation Enhancers for Transdermal Drug Delivery

et al. 2019

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“…Based on our biophysical and chemical-physical backgrounds, we would like to mention that the toxicity of ILs has also stimulated several biophysical and chemical-physical investigations on the interaction between ILs and biomolecules. For example, it has been shown that ILs have the ability to interact with proteins and enzymes (Kumar and Venkatesu 2014 ; Kumar et al 2017 ; Takekiyo and Yoshimura 2018 ; Pillai and Benedetto 2018 ; Bui-Le et al 2020 ; Bharmoria et al 2020 ) and with DNA and RNA (Tateishi-Karimata and Sugimoto 2018 ). Particular attention has been devoted to the investigation of the interaction between ILs and model cell membranes, with a special focus on phospholipid bilayers used as basic/first-order models of cell membranes (Benedetto 2017 ; Wang et al 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of action of ionic liquids on living cells: the state of the art

2020

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Ionic liquids (ILs) are a relatively new class of organic electrolytes composed of an organic cation and either an organic or inorganic anion, whose melting temperature falls around room-temperature. In the last 20 years, the toxicity of ILs towards cells and micro-organisms has been heavily investigated with the main aim to assess the risks associated with their potential use in (industrial) applications, and to develop strategies to design greener ILs. Toxicity, however, is synonym with affinity, and this has stimulated, in turn, a series of biophysical and chemical-physical investigations as well as few biochemical studies focused on the mechanisms of action (MoAs) of ILs, key step in the development of applications in bio-nanomedicine and bio-nanotechnology. This review has the intent to present an overview of the state of the art of the MoAs of ILs, which have been the focus of a limited number of studies but still sufficient enough to provide a first glimpse on the subject. The overall picture that emerges is quite intriguing and shows that ILs interact with cells in a variety of different mechanisms, including alteration of lipid distribution and cell membrane viscoelasticity, disruption of cell and nuclear membranes, mitochondrial permeabilization and dysfunction, generation of reactive oxygen species, chloroplast damage (in plants), alteration of transmembrane and cytoplasmatic proteins/enzyme functions, alteration of signaling pathways, and DNA fragmentation. Together with our earlier review work on the biophysics and chemical-physics of IL-cell membrane interactions (Biophys. Rev. 9:309, 2017), we hope that the present review, focused instead on the biochemical aspects, will stimulate a series of new investigations and discoveries in the still new and interdisciplinary field of “ILs, biomolecules, and cells.”

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“…This is in line with the hypothesis of the silk I structure containing irregular structures and type-II β-turns. The results demonstrate the solvation power of ionic liquids to break hydrogen bonds of hydrophobic β-structures, which has possible applications in many other fields including that of amyloid diseases [ 99 ]. Moreover, the detected loss of structure is an important observation because it presents an unbiased starting point for the biotechnological manipulation of the properties of silk, which can be used as composite material for many biomaterials.…”

Section: Discussionmentioning

confidence: 99%

On the Secondary Structure of Silk Fibroin Nanoparticles Obtained Using Ionic Liquids: An Infrared Spectroscopy Study

et al. 2020

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Silk fibroin from Bombyx mori caterpillar is an outstanding biocompatible polymer for the production of biomaterials. Its impressive combination of strength, flexibility, and degradability are related to the protein’s secondary structure, which may be altered during the manufacture of the biomaterial. The present study looks at the silk fibroin secondary structure during nanoparticle production using ionic liquids and high-power ultrasound using novel infrared spectroscopic approaches. The infrared spectrum of silk fibroin fibers shows that they are composed of 58% β-sheet, 9% turns, and 33% irregular and/or turn-like structures. When fibroin was dissolved in ionic liquids, its amide I band resembled that of soluble silk and no β-sheet absorption was detected. Silk fibroin nanoparticles regenerated from the ionic liquid solution exhibited an amide I band that resembled that of the silk fibers but had a reduced β-sheet content and a corresponding higher content of turns, suggesting an incomplete turn-to-sheet transition during the regeneration process. Both the analysis of the experimental infrared spectrum and spectrum calculations suggest a particular type of β-sheet structure that was involved in this deficiency, whereas the two other types of β-sheet structure found in silk fibroin fibers were readily formed.

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Suppression and dissolution of amyloid aggregates using ionic liquids

Cited by 28 publications

References 58 publications

Ionic Liquids as Potential and Synergistic Permeation Enhancers for Transdermal Drug Delivery

Ionic Liquids as Potential and Synergistic Permeation Enhancers for Transdermal Drug Delivery

Mechanisms of action of ionic liquids on living cells: the state of the art

On the Secondary Structure of Silk Fibroin Nanoparticles Obtained Using Ionic Liquids: An Infrared Spectroscopy Study

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