Suppressing effects of bisphenol A on the secretory function of ovine anterior pituitary cells

Katoh, K.; Matsuda, Akihiro; Ishigami, Akira; Yonekura, Shinichi; Ishiwata, Hiroko; Chen, Chen; Obara, Yoshiaki

doi:10.1016/j.cellbi.2004.03.016

Cited by 13 publications

(10 citation statements)

References 35 publications

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“…Although it was not possible to determine the exact nature and location of action in these studies, Katoh et al . (2004) showed that bisphenol exposure affected growth hormone through an effect exerted at the level of the pituitary gonadotrophes, whereas other studies such as those by Wright et al . (2002) with octylphenol, and Lyche et al .…”

Section: Effects On Animal Physiologymentioning

confidence: 95%

Effects of environmental pollutants on the reproduction and welfare of ruminants

Rhind¹,

Evans²,

Bellingham³

et al. 2010

Animal

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Anthropogenic pollutants comprise a wide range of synthetic organic compounds and heavy metals, which are dispersed throughout the environment, usually at low concentrations. Exposure of ruminants, as for all other animals, is unavoidable and while the levels of exposure to most chemicals are usually too low to induce any physiological effects, combinations of pollutants can act additively or synergistically to perturb multiple physiological systems at all ages but particularly in the developing foetus. In sheep, organs affected by pollutant exposure include the ovary, testis, hypothalamus and pituitary gland and bone. Reported effects of exposure include changes in organ weight and gross structure, histology and gene and protein expression but these changes are not reflected in changes in reproductive performance under the conditions tested. These results illustrate the complexity of the effects of endocrine disrupting compounds on the reproductive axis, which make it difficult to extrapolate between, or even within, species. Effects of pollutant exposure on the thyroid gland, immune, cardiovascular and obesogenic systems have not been shown explicitly, in ruminants, but work on other species suggests that these systems can also be perturbed. It is concluded that exposure to a mixture of anthropogenic pollutants has significant effects on a wide variety of physiological systems, including the reproductive system. Although this physiological insult has not yet been shown to lead to a reduction in ruminant gross performance, there are already reports indicating that anthropogenic pollutant exposure can compromise several physiological systems and may pose a significant threat to both reproductive performance and welfare in the longer term. At present, many potential mechanisms of action for individual chemicals have been identified but knowledge of factors affecting the rate of tissue exposure and of the effects of combinations of chemicals on physiological systems is poor. Nevertheless, both are vital for the identification of risks to animal productivity and welfare.

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Section: Effects On Animal Physiologymentioning

confidence: 95%

Effects of environmental pollutants on the reproduction and welfare of ruminants

Rhind¹,

Evans²,

Bellingham³

et al. 2010

Animal

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“…* P \ 0.05, ** P \ 0.01, as compared with the respective sbGH treatment alone using one-way ANOVA information on the action of BPA on the somatotropic axis. The only study was in ovine pituitary cells showing that BPA could significantly suppress basal and growth hormone releasing hormone (GHRH)-stimulated GH release as well as the cellular GH content (Katoh et al 2004). In the present study, using fish primary hepatocytes and a fish liver cell line, the actions of BPA on the somatotropic axis were delineated at the gene expression and signal transduction levels.…”

Section: Discussionmentioning

confidence: 98%

“…Some reports have shown that BPA, besides disrupting the growth of the comb and testes in male chicken (Furuya et al 2003), could also affect the rat brain somatostatin receptor subtype, which is an important component of the somatotropic axis (Facciolo et al 2002). Further studies on the pituitary, the master gland of the somatotropic axis regulating postnatal growth, demonstrated that BPA possessed suppressive actions on growth hormone (GH) synthesis and release, probably via impairment of the cellular signal transduction systems (Katoh et al 2004). GH exerts its action by binding to the growth hormone receptor (GHR) and activating the post-receptor signaling events.…”

mentioning

confidence: 96%

Disrupting actions of bisphenol A and malachite green on growth hormone receptor gene expression and signal transduction in seabream

Jiao

Chen

2008

Fish Physiol Biochem

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Environmental estrogen could mimic natural estrogens thereby disrupting the endocrine systems of human and animals. The actions of such endocrine disruptors have been studied mainly on reproduction and development. However, estrogen could also affect the somatotropic axis via multiple targets such as growth hormone (GH). In the present study, two endocrine disruptors were chosen to investigate their effects on the expression level and signal transduction of growth hormone receptor (GHR) in fish. Using real-time PCR, it was found that exposure to both the estrogenic (bisphenol A) and anti-estrogenic (malachite green) compounds could attenuate the expression levels of GHR1 and GHR2 in black seabream (Acanthopagrus schlegeli) hepatocytes. The expression level of IGF-I, the downstream effector of GHR activation in the liver, was decreased by bisphenol A but not by malachite green. Luciferase reporter assay of the beta-casein promoter was used to monitor GHR signaling in transfected cells. In the fish liver cell line Hepa-T1, both GHR1 and GHR2 signaling were attenuated by bisphenol A and malachite green. This attenuation could only occur in the presence of estrogen receptor, indicating that these agents probably produce their actions via the estrogen receptor. Results of the present study demonstrated that estrogenic or anti-estrogenic compounds could down-regulate the somatotropic axis in fish by affecting both the gene expression and signaling of GHR. In view of the increasing prevalence of these compounds in the environment, the impact on fish growth and development both in the wild and in aquaculture would be considerable.

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“…Neuroendocrine data in rodents and sheep suggest effects on female hypothalamicpituary-gonadal (HPG) axis organization (≥50 µg/kg b.w. per day, non-oral route) and function (≥5 mg/kg b.w./day, non-oral route), that is at doses higher than the Point of Departure used for TDI derivation (Katoh et al, 2004). The specific mechanisms by which this occurs remain to be identified, but some data suggest that the pattern of luteinizing hormone release may be altered by exposure, resulting in blunted secretion and resistance to feedback.…”

Section: Neurotoxicity and Behavioural Toxicitymentioning

confidence: 99%

The safety of the use of bisphenol A in medical devices

Testai

Hartemann

Rodrı́guez-Farré

et al. 2016

Regulatory Toxicology and Pharmacology

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About the Scientific Committees Three independent non-food Scientific Committees provide the Commission with the scientific advice it needs when preparing policy and proposals relating to consumer safety, public health and the environment. The Committees also draw the Commission's attention to the new or emerging problems which may pose an actual or potential threat. They are: the Scientific Committee on Consumer Safety (SCCS), the Scientific Committee on Health and Environmental Risks (SCHER) and the Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR). In addition, the Commission relies upon the work of the European Food Safety Authority (EFSA), the European Medicines Agency (EMA), the European Centre for Disease prevention and Control (ECDC) and the European Chemicals Agency (ECHA). SCENIHR This Committee deals with questions related to emerging or newly identified health and environmental risks and to broad, complex or multidisciplinary issues requiring a comprehensive assessment of risks to consumer safety or public health and related issues not covered by other Community risk assessment bodies. Examples of potential areas of activity include potential risks associated with interaction of risk factors, synergic effects, cumulative effects, antimicrobial resistance, new technologies such as nanotechnologies, medical devices including those incorporating substances of animal and/or human origin, tissue engineering, blood products, fertility reduction, cancer of endocrine organs, physical hazards such as noise and electromagnetic fields (from mobile phones, transmitters and electronically controlled home environments), and methodologies for assessing new risks. It may also be invited to address risks related to public health determinants and non-transmissible diseases.

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Suppressing effects of bisphenol A on the secretory function of ovine anterior pituitary cells

Cited by 13 publications

References 35 publications

Effects of environmental pollutants on the reproduction and welfare of ruminants

Effects of environmental pollutants on the reproduction and welfare of ruminants

Disrupting actions of bisphenol A and malachite green on growth hormone receptor gene expression and signal transduction in seabream

The safety of the use of bisphenol A in medical devices

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