Suppressing effect of Lactobacillus casei administration on the urinary mutagenicity arising from ingestion of fried ground beef in the human

Hayatsu, Hikoya; Hayatsu, Toshiko

doi:10.1016/0304-3835(93)90261-7

Cited by 125 publications

(52 citation statements)

References 11 publications

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“…Although these studies do show a reduction in faecal enzymes that may be associated with the formation of carcinogens, it is still unclear whether these would affect long-term cancer rates. Reports published to date are not consistent in ®nding reductions in the same enzymes (Goldin & Gorbach, 1984;Lidbeck et al 1992;Hayatsu & Hayatsu, 1993).…”

Section: Probioticsmentioning

confidence: 89%

Perspectives on the role of the human gut microbiota and its modulation by pro- and prebiotics

et al. 2000

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One of the most topical areas of human nutrition is the role of the gut in health and disease. Specifically, this involves interactions between the resident microbiota and dietary ingredients that support their activities. Currently, it is accepted that the gut microflora contains pathogenic, benign and beneficial components. Some microbially induced disease states such as acute gastroenteritis and pseudomembranous colitis have a defined aetiological agent(s). Speculation on the role of microbiota components in disorders such as irritable bowel syndrome, bowel cancer, neonatal necrotising enterocolitis and ulcerative colitis are less well defined, but many studies are convincing. It is evident that the gut microflora composition can be altered through diet. Because of their perceived health-promoting status, bifidobacteria and lactobacilli are the commonest targets. Probiotics involve the use of live micro-organisms in food; prebiotics are carbohydrates selectively metabolized by desirable moieties of the indigenous flora; synbiotics combine the two approaches. Dietary intervention of the human gut microbiota is feasible and has been proven as efficacious in volunteer trials. The health bonuses of such approaches offer the potential to manage many gut disorders prophylactically. However, it is imperative that the best methodologies available are applied to this area of nutritional sciences. This will undoubtedly involve a genomic application to the research and is already under way through molecular tracking of microbiota changes to diet in controlled human trials.

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Section: Probioticsmentioning

confidence: 89%

Perspectives on the role of the human gut microbiota and its modulation by pro- and prebiotics

et al. 2000

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“…The adsorption of HCAs to the plant cell walls increased with increasing hydrophobicity of the HCA (Ferguson et al, 1995;Harris et al, 1996;Hayatsu et al, 1993b). Similarly, chlorophyllin, intestinal microflora and certain bacterial strains contained in fermented foods may decrease the bioavailability of HCAs by direct binding of HCAs to their structure (Hayatsu et al, 1993a;Kassie et al, 2001Kassie et al, , 2004Knasmüller et al, 2001;Orrhage et al, 1994;2002).…”

Section: Assessment Of the Exposure To Hcasmentioning

confidence: 99%

Food Borne Carcinogens: A Dead End?

Busquets¹

2012

Carcinogen

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“…A more recent study demonstrated a reduced uptake of Trp-P-2 and its metabolites in various tissues of mice supplemented with dietary lactic acid bacteria [24] . In addition to that, the consumption of lactobacilli by human volunteers has been shown to reduce the mutagenicity of urine and feces associated with the ingestion of carcinogens in cooked meat [25] . It is possible that the lactic acid bacteria supplements are influencing the uptake and excretion of mutagens by simply binding them in the intestine.…”

Section: Binding and Degrading Potential Carcinogensmentioning

confidence: 99%

Role of probiotics, prebiotics and synbiotics in chemoprevention for colorectal cancer

Fotiadis

Stoidis²,

Spyropoulos³

et al. 2008

WJG

153

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Colorectal cancer is the third most common form of cancer. Current treatments are all associated with a high risk of complications and a low success rate. Recently, synbiotics have been proposed as a new preventive and therapeutic option. There is no direct experimental evidence for cancer suppression in humans as a result of the consumption of pro-, preor synbiotics. However, there is a wealth of evidence emerging from laboratory studies. The mechanisms by which pro-, pre-and synbiotics may inhibit colon cancer are now beginning to be understood and will be addressed in the present review.

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Suppressing effect of Lactobacillus casei administration on the urinary mutagenicity arising from ingestion of fried ground beef in the human

Cited by 125 publications

References 11 publications

Perspectives on the role of the human gut microbiota and its modulation by pro- and prebiotics

Perspectives on the role of the human gut microbiota and its modulation by pro- and prebiotics

Food Borne Carcinogens: A Dead End?

Role of probiotics, prebiotics and synbiotics in chemoprevention for colorectal cancer

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