1993
DOI: 10.1007/bf01200735
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Suppressed cellular immunity in patients with nasopharyngeal carcinoma

Abstract: The subsets and functions of lymphocytes were investigated in patients with nasopharyngeal carcinoma (NPC). The patients were divided into two groups comprising tumor-bearing patients and those in remission. There was no difference in the proportion of T cells among tumor-bearing, remission and healthy control groups. The percentages of inducer/helper T cells and natural killer cells were smaller in the tumor-bearing group than in the control group whereas the percentage of suppressor T cells was greater in th… Show more

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Cited by 27 publications
(15 citation statements)
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“…Markedly elevated concentrations of some toxic trace metals in cancer patients than healthy donors indicate a build-up in the metal levels in cancer patients at the expense of macronutrients, which exhibit lower mean concentrations in the plasma of cancer patients. A decreased plasma Fe in cancer subjects indicates that the utilization of heme molecule was impaired, because the cancer itself might have been affecting the bone marrow function adversely [58]. The statistical distribution parameters evidenced that the metal data in cancer patients are spread over large concentrations as compared with the controls, as reflected by range, S.D., S.E.…”
Section: Resultsmentioning
confidence: 90%
“…Markedly elevated concentrations of some toxic trace metals in cancer patients than healthy donors indicate a build-up in the metal levels in cancer patients at the expense of macronutrients, which exhibit lower mean concentrations in the plasma of cancer patients. A decreased plasma Fe in cancer subjects indicates that the utilization of heme molecule was impaired, because the cancer itself might have been affecting the bone marrow function adversely [58]. The statistical distribution parameters evidenced that the metal data in cancer patients are spread over large concentrations as compared with the controls, as reflected by range, S.D., S.E.…”
Section: Resultsmentioning
confidence: 90%
“…In this context, it will be extremely important to confirm that exosomes carrying LMP1 and/or galectin 9 are released by malignant NPC cells in situ . Moreover, alterations of systemic immunity has been reported in NPC patients [39,40]. It will be important to investigate the presence of LMP1 and/or galectin 9 containing exosomes in the biological fluids of these patients.…”
Section: Discussionmentioning
confidence: 99%
“…Since cellular immunity is suppressed in patients with NPC and the suppressed condition still remains after remission [23], immune suppression might explain the increased incidence of NHL and NMSC after NPC. Although an increased NPC incidence was reported in HIV-infected persons in Africa based on three cases [24], a large study conducted in the US [25] did not show this association.…”
Section: Immune Suppression Hypothesismentioning
confidence: 97%