Supporting Tissue Oxygenation During Acute Surgical Bleeding Using A Perfluorochemical-Based Oxygen Carrier

Abstacts

“…The engraftment kinetics were followed up for each patientand compared to a historical group. The median time to the first signs of engraftment was d+8 (7)(8)(9)(10), to reach 0.5G/l ANC was d+12 (9)(10)(11)(12), to reach >50G/l platelets d+20 (18)(19)(20)(21)(22)(23)(24), all results were not significantly different to the engraftment kinetics of the historical group. Conclusion: The thawing procedure was save also in pediatric and adolescent patients.…”

“…Volunteers experienced mild fluelike symptoms with myalgia and light fever and an approximately 15 % decrease in platelet count 3 days post-dosing returning to normal by day 7 (11,21,24). Traditional coagulation tests, bleeding time and platelet aggregation, however, were unaffected by perflubron emulsion (15,24). Finally, enrollment in a phase III study in cardiac surgery was voluntarily suspended in 2001 due to an apparent dysbalance in adverse neurologic outcome (5).…”

Blood Substitutes

“…In 145 volunteers and 30 surgical patients infused with 0.45-3 g/kg Oxygent™, no relevant adverse effects regarding hematology, coagulation or organ function (liver, kidney, lungs) was observed [46]. Frequently reported side-effects of mild to moderate severity included flu-like symptoms, primarily fever (1-2°C rise in temperature), chills, headache, nausea, and myalgia.…”

Künstliche Sauerstoffträger als Alternative zur Fremdbluttransfusion

“…Ebenso ist das passagere Auftreten grippeähnlicher Symptome mit Fieber, Schüttelfrost, Myalgie, Kopfschmerz und Übelkeit kurze Zeit nach der Zufuhr beschrieben worden. Gewöhnlich sistieren diese Symptome innerhalb von 12-24 h nach ihrem Auftreten spontan [7,24,34]. Die Mehrzahl dieser Symptome kann auch durch Zyklooxygenaseinhibitoren und Kortikosteroide verhindert oder therapiert werden [22].…”