This article presents a review of the literature on Content and Language Integrated Learning (CLIL) from 2011 to 2020. We analyzed 100 research articles based on the First Principles of Instruction (FPI), with the aim of considering the problems of CLIL and exploring the possibilities of improvement based on these principles. We found that the focus of almost all the articles was English as a Foreign Language (EFL) as the target language; rarely was a concern for other languages indicated. Moreover, current studies pertaining to CLIL paid little attention to the FPI. In this article, we offer some suggestions for future research.