Supported Biomembrane Systems Incorporating Multiarm Polymers and Bioorthogonal Tethering
Jesse A. Martin,
Yue-Ming Li,
M. Lane Gilchrist
Abstract:To functionalize interfaces with supported biomembranes and membrane proteins, the challenge is to build stabilized and supported systems that mimic the native lipid microenvironment. Our objective is to control substrate-to-biomembrane spacing and the tethering chemistry so proteoliposomes can be fused and conjugated without perturbation of membrane protein function. Furthermore, the substrates need to exhibit low protein and antibody nonspecific binding to use these systems in assays. We have employed protei… Show more
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