Supported-amine-catalyzed cascade synthesis of spiro-thiazolone-tetrahydrothiophenes: assessing HSA binding activity

Abstract

We have devised a supported-amine catalyzed efficient synthesis of spiro-thiazolone-tetrahydrothiophenes via sulfa-Michael/aldol cascade approach. The catalyst demonstrated a sustained efficacy over 21 cycles. These derivatives were found to exhibit excellent...