Support of the ‘fallopian tube hypothesis’ in a prospective series of risk-reducing salpingo-oophorectomy specimens

Reitsma, Welmoed; Bock, Geertruida H. de; Oosterwijk, Jan C.; Bart, Joost; Hollema, Harry; Mourits, Marian J.E.

doi:10.1016/j.ejca.2012.07.021

Cited by 100 publications

(83 citation statements)

References 40 publications

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“…[9][10][11] In women at high risk (with either BRCA1 or BRCA2 mutations), prophylactic bilateral salpingooophorectomy (BSO) is associated with a reduced risk for breast, ovarian, fallopian tube, and primary peritoneal cancers. [22][23][24][25][26][27] Occult ovarian cancer is sometimes found after prophylactic salpingooophorectomy, thus emphasizing the need for careful pathologic review of the ovaries and tubes (see "Risk-Reducing SalpingoOophorectomy [RRSO] Protocol" in the complete version of these guidelines, available at NCCN.org [OV-A]). [28][29][30][31] The risks of surgery include injury to the bowel, bladder, ureter, and vessels.…”

Section: Epidemiologymentioning

confidence: 99%

Ovarian Cancer, Version 1.2016, NCCN Clinical Practice Guidelines in Oncology

Morgan

Armstrong

Alvarez

et al. 2016

J Natl Compr Canc Netw

300

233

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Section: Epidemiologymentioning

confidence: 99%

Ovarian Cancer, Version 1.2016, NCCN Clinical Practice Guidelines in Oncology

Morgan

Armstrong

Alvarez

et al. 2016

J Natl Compr Canc Netw

300

233

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“…A total of 93 and 100 studies located in the PubMed and Scopus searches were retrieved, respectively, of which 13 studies met the inclusion criteria of our review (2,4,(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). No further studies were retrieved from the Cochrane database.…”

Section: Resultsmentioning

confidence: 99%

“…Genetic counseling and risk-reducing surgery, including prophylactic bilateral salpingo-oophorectomy and mastectomy, are often recommended in BRCA carriers. The median recommended age for prophylactic salpingo-oophorectomy in BRCA carriers is before the age of 40 years (in USA, before 35 years, while in Europe, before 40 years) or certainly after completion of family (2,3). Primary peritoneal cancer is an aggressive malignancy that cannot as yet be diagnosed early with screening tests.…”

Section: Introductionmentioning

confidence: 99%

Primary peritoneal cancer in BRCA carriers after prophylactic bilateral salpingo-oophorectomy

Iavazzo¹,

Gkegkes²,

Vrachnis³

2016

J Turkish German Gynecol Assoc

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Objective:The presence of deleterious mutations in breast cancer (BRCA)-1 or BRCA-2 gene has a decisive influence on the development of various types of neoplasms, such as breast, ovarian, tubal, and peritoneal cancers. Primary peritoneal cancer is an aggressive malignancy which, due to the absence of a specific screening test, cannot be diagnosed in its early stages. As a risk-reducing option, prophylactic bilateral salpingo-oophorectomy and mastectomy are often proposed in BRCA gene carriers. The effectiveness of a preventive surgical treatment is, however, unclear in the development of peritoneal cancer. Material and Methods:An extensive electronic search was performed in PubMed, Scopus, and Cochrane databases. Results: The total number of patients who underwent prophylactic bilateral salpingo-oophorectomy was 1,830, of whom 28 presented with peritoneal cancer (1.53%). The age of the included patients ranged from 48 to 61 years. BRCA-1 was present in 9 out of 28 patients and BRCA-2 in 2 patients, while the type of BRCA was unclear in 17 patients. Salpingo-oophorectomy was performed in 23 out of 28 patients, while oophorectomy was carried out in 5 patients. The interval from initial risk-reducing surgical treatment to the presentation of peritoneal cancer ranged from 12 to 84 months. Conclusion:Modification of the follow-up guidelines and increase in healthcare providers' awareness may reduce the risk of peritoneal cancer. Abstract written only in the English language were included. The reporting data on primary peritoneal cancer in BRCA carriers after prophylactic bilateral salpingo-oophorectomy of the retrieved studies were regarded as includable for this review.

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“…As a result, women more often choose for RRSO and RRM, and also at an earlier age (29). The RRSOs were truly prophylactic because before RRSO all women underwent transvaginal ultrasonography and serum marker CA125 to exclude manifest ovarian cancer (30). Underreporting of preventive surgery in the rest of the Netherlands was very unlikely as medical files of proven carriers were available.…”

Section: Discussionmentioning

confidence: 99%

Variation in Mutation Spectrum Partly Explains Regional Differences in the Breast Cancer Risk of Female BRCA Mutation Carriers in the Netherlands

Vos

Teixeira

Kolk

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

Self Cite

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Background: We aimed to quantify previously observed relatively high cancer risks in BRCA2 mutation carriers (BRCA2 carriers) older than 60 in the Northern Netherlands, and to analyze whether these could be explained by mutation spectrum or population background risk.Methods: This consecutive cohort study included all known pathogenic BRCA1/2 carriers in the Northern Netherlands (N ¼ 1,050). Carrier and general reference populations were: BRCA1/2 carriers in the rest of the Netherlands (N ¼ 2,013) and the general population in both regions. Regional differences were assessed with HRs and ORs. HRs were adjusted for birth year and mutation spectrum.Results: All BRCA1 carriers and BRCA2 carriers younger than 60 had a significantly lower breast cancer risk in the Northern Netherlands; HRs were 0.66 and 0.64, respectively. Above age 60, the breast cancer risk in BRCA2 carriers in the Northern Netherlands was higher than in the rest of the Netherlands [HR, 3.99; 95% confidence interval (CI), 1.11-14.35]. Adjustment for mutational spectrum changed the HRs for BRCA1, BRCA2 <60, and BRCA2 !60 years by À3%, þ32%, and þ11% to 0.75, 0.50, and 2.61, respectively. There was no difference in background breast cancer incidence between the two regions (OR, 1.03; 95% CI, 0.97-1.09).Conclusions: Differences in mutation spectrum only partly explain the regional differences in breast cancer risk in BRCA2 carriers, and for an even smaller part in BRCA1 carriers.Impact: The increased risk in BRCA2 carriers older than 60 may warrant extension of intensive breast screening beyond age 60. Cancer Epidemiol Biomarkers Prev; 23(11); 2482-91. Ó2014 AACR.

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Support of the ‘fallopian tube hypothesis’ in a prospective series of risk-reducing salpingo-oophorectomy specimens

Cited by 100 publications

References 40 publications

Ovarian Cancer, Version 1.2016, NCCN Clinical Practice Guidelines in Oncology

Ovarian Cancer, Version 1.2016, NCCN Clinical Practice Guidelines in Oncology

Primary peritoneal cancer in BRCA carriers after prophylactic bilateral salpingo-oophorectomy

Variation in Mutation Spectrum Partly Explains Regional Differences in the Breast Cancer Risk of Female BRCA Mutation Carriers in the Netherlands

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