2004
DOI: 10.1038/sj.mp.4001608
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Support for involvement of neuregulin 1 in schizophrenia pathophysiology

Abstract: Schizophrenia is a common, multigenic psychiatric disorder. Linkage studies, including a recent meta-analysis of genome scans, have repeatedly implicated chromosome 8p12-p23.1 in schizophrenia susceptibility. More recently, significant association with a candidate gene on 8p12, neuregulin 1 (NRG1), has been reported in several European and Chinese samples. We investigated NRG1 for association in schizophrenia patients of Portuguese descent to determine whether this gene is a risk factor in this population. We … Show more

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Cited by 164 publications
(86 citation statements)
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“…The HapICE risk haplotype is associated with increased expression of NRG1 in the brain (Weickert et al, 2012). Moreover, mRNA and protein of NRG1 are increased in the prefrontal cortex (PFC) and hippocampus of schizophrenia patients (Chong et al, 2008; Hashimoto et al, 2004; Law et al, 2006; Petryshen et al, 2005). The increase did not correlate with antipsychotics treatment (Chong et al, 2008; Law et al, 2006), suggesting an association with the disorder instead of medication.…”
Section: Introductionmentioning
confidence: 99%
“…The HapICE risk haplotype is associated with increased expression of NRG1 in the brain (Weickert et al, 2012). Moreover, mRNA and protein of NRG1 are increased in the prefrontal cortex (PFC) and hippocampus of schizophrenia patients (Chong et al, 2008; Hashimoto et al, 2004; Law et al, 2006; Petryshen et al, 2005). The increase did not correlate with antipsychotics treatment (Chong et al, 2008; Law et al, 2006), suggesting an association with the disorder instead of medication.…”
Section: Introductionmentioning
confidence: 99%
“…Separate follow-up studies in Scottish, Irish, mixed United Kingdom, and Dutch populations confirmed the genetic association between schizophrenia and NRG1 by using markers within the same core haplotype (11)(12)(13)(14) or with overlapping markers in the 5Ј region (15,16). Studies in four Asian populations also showed a strong association between schizophrenia and NRG1 polymorphisms at the 5Ј (17)(18)(19)(20) and 3Ј end of the gene (19).…”
mentioning
confidence: 74%
“…Furthermore, genetic linkage and association studies led to the identification of two additional susceptibility factors related to schizophrenia, such as neuregulin-1 ( NRG1 ) and its receptor ErbB4 [226,227]. NRG1 is a family of trophic factors that is synthesized as trans-membrane proteins displaying an extracellular epidermal growth factor (EGF)-like domain that is essential for ErbB4 receptor binding.…”
Section: Mtor Modulation Of Dopamine Transmission In Methamphetamimentioning
confidence: 99%