2004
DOI: 10.1038/sj.mp.4001661
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Support for involvement of neuregulin 1 in schizophrenia pathophysiology

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Cited by 46 publications
(73 citation statements)
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“…9,[23][24][25][26][27][28][29]52 Two of the five SNPs defining the at-risk haplotype previously reported 9 were included in this study, SNPnrg2 and SNPnrg4. These two SNPs plus three additional ones typed in this study were located in the area of Hap ICE .…”
Section: Resultsmentioning
confidence: 99%
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“…9,[23][24][25][26][27][28][29]52 Two of the five SNPs defining the at-risk haplotype previously reported 9 were included in this study, SNPnrg2 and SNPnrg4. These two SNPs plus three additional ones typed in this study were located in the area of Hap ICE .…”
Section: Resultsmentioning
confidence: 99%
“…This finding was replicated in a follow-up study in a Scottish population, 23 and a succession of replication studies in additional populations ensued, including studies in a number of Chinese populations, [24][25][26] an Irish population, 27 a population from the British Isles, 28 and a Portuguese population. 29,30 However, neither these nor the original study have identified the putative disease-causing variant within NRG1. This implies that either the disease-causing variant is carried on the susceptibility haplotype or that it is in linkage disequilibrium (LD) with it.…”
Section: Introductionmentioning
confidence: 99%
“…59 Briefly, the sample consisted of primary leukocyte cell preparations from 33 age-and gender-matched sibling pairs (22 female, 11 male pairs; 32 schizophrenia and one SA-D discordant pairs) selected from our linkage pedigrees. 32 Of the 33 sibpairs, 32 sibpairs were also genotyped for the same set of markers as the association sample.…”
Section: Subjectsmentioning
confidence: 99%
“…A combined standard normal Z-score was calculated, where the sum of the deviations from expected frequencies (under the null hypothesis of no association) of each sample was divided by the sum of the variances of each sample, as previously described. 59,85 Nominal significance levels were obtained from the Z distribution. This approach provided SNP allele-or haplotype-specific nominal significance levels.…”
Section: Genotypingmentioning
confidence: 99%
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