Support for and implications of the specific plaque hypothesis

Emilson, Claes‐Göran; Krasse, Bo

doi:10.1111/j.1600-0722.1985.tb01316.x

Cited by 71 publications

(74 citation statements)

References 60 publications

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“…These same bacteria are also acid tolerant and therefore could survive the low pH observed in carious lesions. While the mutans streptococci are considered to be the prime suspects in the caries process (Emilson and Krasse, 1985;Hamada and Slade, 1980;Loesche, 1976), Actinomyces have also been shown to be cariogenic in animal models and have been associated with root caries (Jordan, 1986). Recent work has also supported the role of acid-tolerant nonmutans streptococci in the caries process (Sansone et al, 1993).…”

Section: The Specificity Of Oral Bacterial Colonizationmentioning

confidence: 91%

Saliva-Bacterium Interactions in Oral Microbial Ecology

Scannapieco

1994

Critical Reviews in Oral Biology & Medicine

283

250

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Saliva is thought to have a significant impact on the colonization of microorganisms in the oral cavity. Salivary components may participate in this process by one of four general mechanisms: binding to microorganisms to facilitate their clearance from the oral cavity, serving as receptors in oral pellicles for microbial adhesion to host surfaces, inhibiting microbial growth or mediating microbial killing, and serving as microbial nutritional substrates. This article reviews information pertinent to the molecular interaction of salivary components with bacteria (primarily the oral streptococci and Actinomyces) and explores the implications of these interactions for oral bacterial colonization and dental plaque formation. Knowledge of the molecular mechanisms controlling bacterial colonization of the oral cavity may suggest methods to prevent not only dental plaque formation but also serious medical infections that may follow microbial colonization of the oral cavity.

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Section: The Specificity Of Oral Bacterial Colonizationmentioning

confidence: 91%

Saliva-Bacterium Interactions in Oral Microbial Ecology

Scannapieco

1994

Critical Reviews in Oral Biology & Medicine

283

250

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“…This result reinforces the multifactorial characteristics of dental caries etiology. Moreover, we must consider the specific plaque hypothesis and the role of cariogenic microorganisms in the dental caries process 6 . According to this hypothesis, the composition of the dental biofilm is more important than its quantity for this disease's etiology.…”

Section: Discussionmentioning

confidence: 99%

Correlation among mutans streptococci counts, dental caries, and IgA to Streptococcus mutans in saliva

Koga-Ito¹,

Martins²,

Balducci

et al. 2004

Braz. oral res.

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Two-hundred and forty individuals were studied, divided into five groups as follows: caries-free children, children with caries, children with rampant caries, young adults with and without caries. Whole stimulated saliva was collected and all individuals were investigated for DMFT/dmft according to the WHO criteria and the simplified oral hygiene index (OHI-S). Quantitative analysis of the total aerobic flora and mutans streptococci in saliva was performed. Also, the level of salivary anti-S. mutans IgA was determined by ELISA. Children with rampant caries showed the highest OHI-S value. The highest total counts of microorganisms were found in the group of children with caries. No statistically significant differences were observed for salivary flow, OHI-S and microorganism counts between the groups of young adults. No correlation between mutans streptococci counts and anti-Streptococcus mutans IgA levels was observed in the studied groups. A correlation between increased anti-Streptococcus mutans IgA levels and caries-free status was observed among young adults but not among children. DESCRIPTORS: Streptococcus mutans; IgA; Saliva. RESUMO:Duzentos e quarenta indivíduos divididos em cinco grupos foram estudados: crianças livres de cáries, crianças com cáries, crianças com cáries rampantes, adultos jovens com e sem cáries. Saliva total estimulada foi coletada, e todos os indivíduos foram investigados para CPO-D/ceo-d seguindo-se os critérios da OMS e o índice de higiene oral simplificado (IHOS). Foi também realizada a quantificação da microbiota aeróbica total e de estreptococos do grupo mutans na saliva. Além disso, o nível de IgA anti-S. mutans foi determinado por ELISA. Crianças com cárie rampante apresentaram maior valor de IHOS. A contagem total de microrganismos mais elevada foi encontrada no grupo de crianças com cárie. Nenhuma diferença estatisticamente significativa foi observada em relação a fluxo salivar, IHOS e contagens de microrganismos entre os grupos de adultos jovens. Nenhuma correlação entre contagem de estreptococos do grupo mutans e níveis de IgA anti-Streptococcus mutans foi observada em nenhum dos grupos estudados. Foi encontrada uma correlação entre níveis mais altos de IgA anti-S. mutans e ausência de cáries entre os adultos jovens, mas não entre as crianças.

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“…(2) Microbial effects Several micro-organisms are associated with caries lesions, especially mutans streptococci (S. mutans S sobrinus) and lactobacilli (Emilson and Krasse, 1985).…”

Section: (Vi) Dentin Adhesives (A) Composition and Release Of Substancesmentioning

confidence: 99%

Biocompatibility of Resin-Modified Filling Materials

Geurtsen

2000

Critical Reviews in Oral Biology & Medicine

359

258

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Increasing numbers of resin-based dental restorations have been placed over the past decade. During this same period, the public interest in the local and especially systemic adverse effects caused by dental materials has increased significantly It has been found that each resin-based material releases several components into the oral environment. In particular, the comonomer, triethyleneglycol di-methacrylate (TEGDMA), and the 'hydrophilic' monomer, 2-hydroxy-ethyl-methacrylate (HEMA), are leached out from various composite resins and 'adhesive' materials (e.g., resin-modified glass-ionomer cements IGICsl and dentin adhesives) in considerable amounts during the first 24 hours after polymerization. Numerous unbound resin components may leach into saliva during the initial phase after polymerization, and later, due to degradation or erosion of the resinous restoration. Those substances may be systemically distributed and could potentially cause adverse systemic effects in patients. In addition, absorption of organic substances from unpolymerized material, through unprotected skin, due to manual contact may pose a special risk for dental personnel. This is borne out by the increasing numbers of dental nurses, technicians, and aentists who present with allergic reactions to one or more resin components, like HEMA, glutaraldehyde, ethyleneglycol di-methacrylate (EGDMA), and dibenzoyl peroxide (DPO). However, it must be emphasized that, except for conventional composite resins, data reported on the release of substances from resin-based materials are scarce. There is very little reliable information with respect to the biological interactions between resin components and various tissues. Those interactions may be either protective, like absorption to dentin, or detrimental, e.g., inflammatory reactions of soft tissues. Microbial effects have also been observed which may contribute indirectly to caries and irritation of the pulp. Therefore, it is critical, both for our patients and for the profession, that the biological effects of resin-based filling materials be clarified in the near future,

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Support for and implications of the specific plaque hypothesis

Cited by 71 publications

References 60 publications

Saliva-Bacterium Interactions in Oral Microbial Ecology

Saliva-Bacterium Interactions in Oral Microbial Ecology

Correlation among mutans streptococci counts, dental caries, and IgA to Streptococcus mutans in saliva

Biocompatibility of Resin-Modified Filling Materials

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