Suppmentary Materials and Methods and Supplementary Figures 1 through 6 from Destabilization of Fatty Acid Synthase by Acetylation Inhibits <i>De Novo</i> Lipogenesis and Tumor Cell Growth
Abstract:<p>Supplementary experimental procedures; Figure S1. Acetylation promotes polyubiquitylation and protein degradation of FASN; Figure S2. KAT3A, KAT3B and HAT1 do not interact with FASN; Figure S3. HDAC3 regulates acetylation and protein stability of FASN; Figure S4. TRIM21 interacts and promotes polyubiquitylation of FASN; Figure S5. Raman spectra of lipid and protein signals in the cell; Figure S6. Clinical cases with decreased FASN acetylation, increased FASN and HDAC3 poteins, as well as a moderate in… Show more
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