Supply chains in life‐science applications

Abstract

The systemic investigation of the energy metabolism in the frame of the selfish-brain theory focusses on supply chains from the energy exploration in the remote environment to the energy consumption by neurons in the brain. Modelling this, the main difficulty consists in the selection of significant core models among the enormous number of known substances and regulatory mechanisms, which are afflicted with considerable incertainties in general. We investigate general supply chains and deduce indispensable elements in the regulatory mechanisms from available observations. A critical selection of system properties and underlying mechanisms enables us to simulate observations, which cannot be explained by the classical glucastatic and lipostatic theory. These observations are e. g. the nearly constant energy level in the brain, the different response of the periphery and the brain to atrophic periods and finally, the development of diabetes.