Many supply chains have been disrupted due to the outbreak of COVID-19, especially the cold chain that requires more conditions to operate and is facing more challenges. This chapter will start with the situation of cold chain, explore the risks and concerns of cold chain when it comes to COVID-19 and what additional requirements cold chain transportation requires compared with ordinary supply chain. Digital transformation is also an object worthy of attention. This chapter will also focus on how digital transformation creates value for cold supply chain transportation. At the same time, this chapter will summarize how the added value of the digital cold chain responds to food safety, select some cases of enterprises in China that have used digital technology to improve the resilience of the cold chain during the epidemic to provide a reference for enterprises and countries that need to improve the cold chain resilience.