Supplements of l-arginine attenuate the effects of high-fat meal on endothelial function and oxidative stress

Response to Letters Regarding Article, “Evidence for Statin Pleiotropy in Humans: Differential Effects of Statins and Ezetimibe on Rho-Associated Coiled-Coil Containing Protein Kinase Activity, Endothelial Function, and Inflammation”

“…The intra-and interobserver variability were 0.9% and 1.4%, respectively. 12,13 Although the sample size of our study was relatively small, the reproducibility was quite high. In terms of LDL-C changes in our study, the lipid-lowering response to statin monotherapy and a combination of statin and ezetimibe may differ between white and Asian patients.…”

L-Arginine Supplementation Alleviates Postprandial Endothelial Dysfunction When Baseline Fasting Plasma Arginine Concentration Is Low: A Randomized Controlled Trial in Healthy Overweight Adults with Cardiometabolic Risk Factors

“…Postprandial dysfunction has been observed after a high-fat meal in healthy adults and more markedly in those with risk factors associated with the metabolic syndrome (19)(20)(21)(22)(23)(24). However, to our knowledge, few studies have evaluated the effects of arginine supplementation during the postprandial period (25), particularly following low doses of supplementation (26,27), and none have been conducted in subjects with cardiometabolic risk factors.…”

The effects on plasma L-arginine levels of combined oral L-citrulline and L-arginine supplementation in healthy males

“…L-Arginine is a conditionally essential amino acid that has a variety of effects, including improved endothelial function, [1][2][3] enhanced sport performance, 4,5) improved insulin resistance, 6,7) and improved erectile function. 8) However, relatively large doses of Larginine are required to produce these effects in humans.…”