2021
DOI: 10.1016/j.anireprosci.2021.106715
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Supplementing pregnant Merino ewes with caffeine to improve neonatal lamb thermoregulation and viability

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Cited by 7 publications
(4 citation statements)
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“…The maternal supplementation of caffeine is another approach suggested to improve newborn health. In Merino ewes, caffeine at 20 mg/kg resulted in lambs with higher rectal temperatures (p = 0.021), greater immunoglobulin concentrations (p = 0.041), and more suckling attempts than control animals and those receiving only 10 mg/kg [93]. A similar result was reported by Dearlove et al [94] in piglets from sows receiving 2g of caffeine three days before farrowing.…”
Section: Future Directionssupporting
confidence: 76%
“…The maternal supplementation of caffeine is another approach suggested to improve newborn health. In Merino ewes, caffeine at 20 mg/kg resulted in lambs with higher rectal temperatures (p = 0.021), greater immunoglobulin concentrations (p = 0.041), and more suckling attempts than control animals and those receiving only 10 mg/kg [93]. A similar result was reported by Dearlove et al [94] in piglets from sows receiving 2g of caffeine three days before farrowing.…”
Section: Future Directionssupporting
confidence: 76%
“…Moreover, studies in neonate humans have shown that plasma half-life and metabolism of caffeine are longer compared with adults or animals [39]. In this sense, Murdock et al [28] analyzed the optimal concentration and duration of caffeine to improve lamb viability, finding that 20 mg/kg administered at day 120 of gestation increased lambs' RT, as well as the attempts to suck colostrum and suction time. Accordingly, caffeine metabolism in the newborn can be considered less efficient due to a lower expression of the CYP1A2 protein enzymes, responsible for drug biotransformation, resulting in lower production of active metabolites such as theophylline and theobromine, the main caffeinederived effectors.…”
Section: Discussionmentioning
confidence: 99%
“…In contrast, in veterinary medicine, the relation between the respiratory stimulatory effect and the improvement in vitality when using caffeine has not been completely established, since there is no defined therapeutic dose to improve the vigor of newborn animals with low birthweight [10,27]. Nonetheless, different doses (e.g., 10-27 mg/kg) of caffeine have recently been studied to reduce neonatal cardiorespiratory alterations [28][29][30][31]. In a study carried out in piglets by Jarrat el al.…”
Section: Introductionmentioning
confidence: 99%
“…For example, a study evaluated the optimal concentration and duration of caffeine in Merino ewes at 120 and 140 days of gestation. In animals receiving 10 or 20 mg/kg of caffeine in the feed at 120 days of gestation and 20 mg/kg after 140 days of gestation, it was observed that the high administration of caffeine from day 120 allowed the lambs to present a higher rectal temperature, greater suckling attempts, and a longer sucking time [153]. This suggests that caffeine administration during late pregnancy would be a more viable option to guarantee its effectiveness in the newborn.…”
Section: Caffeinementioning
confidence: 99%