Supplementing intensive targeted computerized cognitive training with social cognitive exercises for people with schizophrenia: An interim report.

Fisher, Melissa; Nahum, Mor; Howard, Elizabeth R.; Rowlands, Abby; Brandrett, Benjamin; Kermott, Amy; Woolley, Joshua; Vinogradov, Sophia

doi:10.1037/prj0000244

Cited by 44 publications

(47 citation statements)

References 72 publications

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“…A similar study by Fisher et al evaluated targeted cognitive training, specifically auditory and visual processing training and CSCT compared with targeted cognitive training alone. 44 These authors did not find that a combined intervention demonstrated significantly more improvement in most domains of cognition and functioning, although they did find that combined training resulted in greater improvements in reward processing, specifically increased consummatory and anticipatory pleasure, which have been linked to motivated and goal-directed behavior, as well as prosody identification. This was significant because of past findings suggesting that the relationship between social cognition and social functioning is mediated by the level of motivation, with more support for the theory that poor socialcognitive abilities impeded motivation, leading to poor functioning.…”

Section: Training Interventions Aimed At Cognition and Social Cognitionmentioning

confidence: 95%

Neurocognition and social cognition training as treatments for violence and aggression in people with severe mental illness

Jones

Harvey

2019

CNS Spectr.

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Aggressive and violent behavior, including both verbal and physical aggression, have considerable adverse consequences for people with schizophrenia. There are several potential causes of violent behavior on the part of people with severe mental illness, which include intellectual impairments, cognitive and social-cognitive deficits, skills deficits, substance abuse, antisocial features, and specific psychotic features. This review explores the interventions that have been tested to this date. Computerized Cognitive Training (CCT) or Computerized Social-Cognitive Training (CSCT) have been associated with reductions in violence. Combined CCT and CSCT have been found to improve social cognition and neurocognition, as well as everyday functioning when combined with rehabilitation interventions. These interventions have been shown to reduce violence in schizophrenia patients across multiple environments, including forensic settings. The reductions in violence and aggression have manifested in various ways, including reduced violent thinking and behavior, reduced physical and violent assaults, and reduced disruptive and aggressive behaviors. Effects of cognitive training may be associated with improvements in problem-solving and the increased ability to deploy alternative strategies. The effect of social cognition training on violence reduction appears to be direct, with improvements in violence related to the extent of improvement in social cognition. There are still remaining issues to be addressed in the use of CCT and CSCT, and the benefits should not be overstated; however, the results of these interventions are very promising.

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Section: Training Interventions Aimed At Cognition and Social Cognitionmentioning

confidence: 95%

Neurocognition and social cognition training as treatments for violence and aggression in people with severe mental illness

Jones

Harvey

2019

CNS Spectr.

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Section: Reward Learning In Schizophreniamentioning

confidence: 99%

“…Several recent studies have looked at effects of remediation on social reward processing in schizophrenia [73,74]. Vinogradov and colleagues paired computerized social cognitive training with "cold" cognitive training [73,74] because of previous studies suggesting that poor social cognitive abilities may impede motivation and lead to poor functioning [73]. Greater improvements in both cold cognition (e.g., prosody identification) and self-reported reward processing were found following the combined treatment than following cognitive treatment alone [73] which were sustained at six-month follow up [74].…”

Section: Reward Learning In Schizophreniamentioning

confidence: 99%

Grant Report on Social Reward Learning in Schizophrenia

Butler

Hoptman

Smith

et al. 2020

J Psychiatry Brain Sci

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We report on the ongoing R21 project "Social Reward Learning in Schizophrenia". Impairments in social cognition are a hallmark of schizophrenia. However, little work has been done on social reward learning deficits in schizophrenia. The overall goal of the project is to assess social reward learning in schizophrenia. A probabilistic reward learning (PRL) task is being used in the MRI scanner to evaluate reward learning to negative and positive social feedback. Monetary reward learning is used as a comparison to assess specificity. Behavioral outcomes and brain areas, included those involved in reward, are assessed in patients with schizophrenia or schizoaffective disorder and controls. It is also critical to determine whether decreased expected value (EV) of social stimuli and/or reward prediction error (RPE) learning underlie social reward learning deficits to inform potential treatment pathways. Our central hypothesis is that the pattern of social learning deficits is an extension of a more general reward learning impairment in schizophrenia and that social reward learning deficits critically contribute to deficits in social motivation and pleasure. We hypothesize that people with schizophrenia will show impaired behavioral social reward learning compared to controls, as well as decreased ventromedial prefrontal cortex (vmPFC) EV signaling at time of choice and decreased striatal RPE signaling at time of outcome, with potentially greater impairment to positive than negative feedback. The grant is in its second year. It is hoped that this innovative approach may lead to novel and more targeted

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“…Results from the pilot study indicated significant improvements on prosody identification, facial memory, social functioning, motivation and reward sensitivity ( Nahum et al, 2014 ). More recently, a randomized controlled trial found that supplementing CT with these social cognitive exercises in people with psychotic disorders confers greater benefits in prosody identification and reward processing relative to CT alone( Fisher et al, 2017 ). While preliminary evidence indicates that CT is efficacious, access to and engagement with CT by individuals with SZ remain outstanding challenges.…”

Section: Introductionmentioning

confidence: 99%

Feasibility and preliminary efficacy of remotely delivering cognitive training to people with schizophrenia using tablets

Biagianti

Fisher

Howard

et al. 2017

Schizophrenia Research: Cognition

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BackgroundLimited access to Cognitive Training (CT) for people with schizophrenia (SZ) prevents widespread adoption of this intervention. Delivering CT remotely via tablets may increase accessibility, improve scheduling flexibility, and diminish patient burden.MethodsIn this reanalysis of data from a larger trial of CT, we compared two samples of individuals with SZ who chose to complete 40 h of CT either on desktop computers in the laboratory (N = 33) or remotely via iPads (N = 41). We examined attrition rates and adherence to training, and investigated whether remote iPad-based CT and in-person desktop-based CT induced significantly different improvements in cognitive and real-world functioning.ResultsThe attrition rate was 36.6%. On average, participants completed 3.06 h of CT per week. There were no significant between-group differences in attrition and adherence to CT requirements. Participants who completed iPad-based CT were significantly younger and had lower symptoms at baseline compared to participants who completed CT on the lab desktops. Controlling for age and symptom severity, rANCOVA showed that iPad-based and desktop-based CT similarly and significantly improved verbal learning and problem solving. Main effects of time, at trend level significance, were evident in global cognition, verbal memory, quality of life, and social functioning. All group by time interactions were non-significant except for verbal memory, where iPad users showed greater gains. Within-group effect sizes for changes in outcomes were in the small range.ConclusionAlthough underpowered and not randomized, this study demonstrates that delivering CT remotely to people with SZ using tablets is feasible and results in retention rates, adherence, and cognitive and functional outcome improvements that are comparable to those observed when CT is delivered in the laboratory. This has important implications in terms of scalability and dissemination of CT. These results require confirmation in larger samples.

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Supplementing intensive targeted computerized cognitive training with social cognitive exercises for people with schizophrenia: An interim report.

Cited by 44 publications

References 72 publications

Neurocognition and social cognition training as treatments for violence and aggression in people with severe mental illness

Neurocognition and social cognition training as treatments for violence and aggression in people with severe mental illness

Grant Report on Social Reward Learning in Schizophrenia

Feasibility and preliminary efficacy of remotely delivering cognitive training to people with schizophrenia using tablets

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