Supplementing capsaicin with chitosan-based films enhanced the anti-quorum sensing, antimicrobial, antioxidant, transparency, elasticity and hydrophobicity

Akyüz, Lalehan; Kaya, Murat; Mujtaba, Muhammad; Torun, Ilker; Sargın, İdris; Salaberria, Asier M.; Labidi, Jalel; Çakmak, Yavuz Selim; İşlek, Cemil

doi:10.1016/j.ijbiomac.2018.04.040

Cited by 60 publications

(26 citation statements)

References 50 publications

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“…In a previous study, a significant increase was observed in the antioxidant activities of the films obtained by adding capsaicin to the polyurethane film [63]. In another study, the inhibition rate of DPPH increased from 31.72% in the control group to 94.40% by adding different amounts of capsaicin to chitosanbased films [64]. According to the data obtained in the present study, free radical removal and antioxidant activity of the CPC film was increased by loading capsaicin in accordance with previous studies.…”

Section: Antioxidantmentioning

confidence: 87%

Natural β-chitin-protein complex film obtained from waste razor shells for transdermal capsaicin carrier

Aylanç

Ertosun

Akyüz

et al. 2020

International Journal of Biological Macromolecules

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In the literature, the produced β-chitin samples are in powder or flake forms but there is no natural β-chitin based film. Also, the commercially available transdermal patches are produced from synthetic polymers. In this regard, we produced natural β-chitin-protein complex (CPC) film from the waste shells of Ensis spp. The obtained natural film was characterized by FTIR, TGA and SEM. Additionally, swelling, thickness, contact angle and antioxidant tests were done to learn more about the films. After production and characterization of the film, capsaicin, which is commonly used for pain relief was loaded into the film. The loading capacity was recorded as 5.79%. The kinetic models were studied in three different pH, then the results were fitted with Higuchi model with high correlation at pH 7.4. After considering all the obtained results, the capsaicin loaded CPC film may be an alternative candidate for transdermal patch instead of the synthetic ones.

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Section: Antioxidantmentioning

confidence: 87%

Natural β-chitin-protein complex film obtained from waste razor shells for transdermal capsaicin carrier

Aylanç

Ertosun

Akyüz

et al. 2020

International Journal of Biological Macromolecules

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“…Priyadarshi et al have reported the incorporation of citric acid as an active ingredient for the extension of green chili shelf life [178]. Examples of grafting/incorporating chitosan-based films with hydroxybenzoic acid [192], protocatechuic acid [188,207], gallic acid [167], or even capsaicin -an active substance isolated from chili peppers [182], have been also reported throughout the literature. However, the highest improvements of the antioxidant activity have been observed after the incorporation of AAs such as protein hydrolysates and propolis extract ( Figure 2).…”

Section: Antioxidant Activity Of Chitosan-and Alginate-based Films Wimentioning

confidence: 98%

From waste/residual marine biomass to active biopolymer-based packaging film materials for food industry applications – a review

Novak

Bajić

Kõrge

et al. 2019

Physical Sciences Reviews

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Abstract Waste/residual marine biomass represents a vast and potentially underexplored source of biopolymers chitin/chitosan and alginate. Their isolation and potential application in the development and production of bio-based food packaging are gaining in attractiveness due to a recent increment in plastic pollution awareness. Accordingly, a review of the latest research work was given to cover the pathway from biomass sources to biopolymers isolation and application in the development of active (antimicrobial/antioxidant) film materials intended for food packaging. Screening of the novel eco-friendly isolation processes was followed by an extensive overview of the most recent publications covering the chitosan- and alginate-based films with incorporated active agents.

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“… 94 Moreover, chitosan and its derivatives have an anti-biofilm activity. 95 , 96 Also, the antimicrobial properties of chitosan, due to the presence of its positive charge amino groups, can react with negatively charged lipopolysaccharides of P. aeruginosa , which can consequently inhibit the bacterial proliferation. 85 , 97 Chitosan derivatives such as chitosan NPs have also shown biological activities against microorganisms.…”

Section: Synthetic Compoundsmentioning

confidence: 99%

<p>Quorum Quenching: A Potential Target for Antipseudomonal Therapy</p>

Hemmati¹,

Salehi²,

Ghotaslou³

et al. 2020

IDR

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There has been excessive rate of use of antibiotics to fight Pseudomonas aeruginosa (P. aeruginosa) infections worldwide, which has consequently caused the increased resistance to multiple antibiotics in this pathogen. Due to the widespread resistance and the current poor effect of antibiotics consumed to treat P. aeruginosa infections, finding some novel alternative therapeutic methods are necessary for the treatment of infections. The P. aeruginosa biofilms can cause severe infections leading to the increased antibiotic resistance and mortality rate among the patients. In this regard, there are no approaches that can efficiently manage these infections; therefore, novel and effective antimicrobial and antibiofilm agents are needed to control and treat these bacterial infections. Quorum sensing inhibitors (QSIs) or quorum quenchings (QQs) are now considered as potential therapeutic alternatives and/or adjuvants to the current failing antibiotics, which can control the virulence traits of the pathogens, so as a result, the host immune system can quickly eliminate bacteria. Thus, the aims of this review article were presenting a brief explanation of the research reports on the natural and synthetic QSIs of P. aeruginosa, and the assessment of the current understanding on the QS mechanisms and various QQ strategies in P. aeruginosa.

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Supplementing capsaicin with chitosan-based films enhanced the anti-quorum sensing, antimicrobial, antioxidant, transparency, elasticity and hydrophobicity

Cited by 60 publications

References 50 publications

Natural β-chitin-protein complex film obtained from waste razor shells for transdermal capsaicin carrier

Natural β-chitin-protein complex film obtained from waste razor shells for transdermal capsaicin carrier

From waste/residual marine biomass to active biopolymer-based packaging film materials for food industry applications – a review

<p>Quorum Quenching: A Potential Target for Antipseudomonal Therapy</p>

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