Supplementing alpha-tocopherol (vitamin E) and vitamin D3 in high fat diet decrease IL-6 production in murine epididymal adipose tissue and 3T3-L1 adipocytes following LPS stimulation

Lira, Fábio Santos; Rosa, José César; Cunha, Carolina; Ribeiro, Eliane; Nascimento, Claudia Oller do; Oyama, Lila Missae; Mota, João Felipe

doi:10.1186/1476-511x-10-37

Cited by 77 publications

(93 citation statements)

References 39 publications

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“…Such an effect could be mediated via inhibition of the NF-κB pathway. This observation was in line with a previous study that reported an anti-inflammatory effect (decreased IL-6 and increased IL-10 expression in adipose tissue) of vitamin E (α-tocopherol) in vivo in mice fed a high fat diet, as well as in 3T3-L1 adipocytes stimulated by lipopolysaccharides (decreased IL-6) [137]. …”

Section: Vitamin Esupporting

confidence: 92%

Lipophilic Micronutrients and Adipose Tissue Biology

2012

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Lipophilic micronutrients (LM) constitute a large family of molecules including several vitamins (A, D, E, K) and carotenoids. Their ability to regulate gene expression is becoming increasingly clear and constitutes an important part of nutrigenomics. Interestingly, adipose tissue is not only a main storage site for these molecules within the body, but it is also subjected to the regulatory effects of LM. Indeed, several gene regulations have been described in adipose tissue that could strongly impact its biology with respect to the modulation of adipogenesis, inflammatory status, or energy homeostasis and metabolism, among others. The repercussions in terms of health effects of such regulations in the context of obesity and associated pathologies represent an exciting and emerging field of research. The present review will focus on the regulatory effects of vitamin A, D, E and K as well as carotenoids on adipose tissue biology and physiology, notably in the context of obesity and associated disorders.

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Section: Vitamin Esupporting

confidence: 92%

Lipophilic Micronutrients and Adipose Tissue Biology

2012

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“…These data suggest that high BFP in conjunction with low vitamin D levels exerts a detrimental effect on exercise performance in athletes as well as in the general population. It should be noted that increased BFP is associated with the development of a systemic chronic low-grade inflammation and insulin resistance, a characteristic of obesity, which also negatively affect exercise performance [148].…”

Section: Implications For Physical Activity/exercise Performancementioning

confidence: 99%

Vitamin D and Physical Activity

Koundourakis¹,

Margioris²

2017

A Critical Evaluation of Vitamin D - Basic Overview

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Vitamin D is synthesized in the skin following exposure to ultraviolet radiation, producing cholecalciferol, while only a small percentage of the circulating vitamin D is of exogenous origin deriving from food. Following two sequential hydroxylations, in the liver and in the kidneys, vitamin D is fully activated. Although its role in bone physiology and calcium homeostasis is well documented, there is emerging evidence that vitamin D exerts a plethora of additional effects on most tissues regulating the musculoskeletal, cardiovascular, and immune systems as well as energy homeostasis. Its deficiency/insufficiency poses a major public health problem observed in all age groups and regardless of latitude and insolation. In muscles, vitamin D deficiency is associated with a decline in neuromuscular function including muscular strength, walking speed, balance, jumping and sprinting performance, and aerobic capacity, although the evidence is still weak regarding its effects in the young and the athletes. Supplementation counteracts the negative effects of vitamin D deficiency on performance although in individuals with adequate levels of vitamin D, additional supplementation does not appear to enhance further physical capabilities. The aim of this chapter is to review our current understanding of diverse effects of vitamin D in physical performance in athletic and nonathletic populations.

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“…Nutritional interventions, including calorie restriction, vitamin supplementation, fresh green tea or extract consumption are often utilised to promote weight loss [2, 5–7]. …”

Section: Introductionmentioning

confidence: 99%

Metabolic profile response to administration of epigallocatechin-3-gallate in high-fat-fed mice

Moreno

Okuda

Lira

et al. 2014

Diabetol Metab Syndr

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BackgroundObesity is associated with increased adipose tissue and glucose intolerance. High-fat diets (HFDs) are known to induce obesity and increase proinflammatory adipokines. The consumption of green tea may improve the health of obese individuals because it contains a potent antioxidant that has effects on body weight, energy expenditure and serum cholesterol concentrations.MethodsWe examined the effects of epigallocatechin-3-gallate (EGCG) (50 mg/kg body weight per day) or saline after 30 or 60 days of treatment. Mice were distributed into four groups: 1) NS: normolipidic diet receiving saline; 2) NE: normolipidic diet receiving EGCG; 3) HFS: high-fat diet receiving saline; 4) HFE: high-fat diet receiving EGCG.ResultsWe observed that administration of a HFD plus EGCG treatment for 60 days reduced delta weight, the relative weights of the mesenteric adipose tissue (MES), retroperitonial adipose tissue (RET), epididymal adipose tissue (EPI), the sum of the adipose tissues (SAT), reduced triacylglycerol (TG) and improved both high-density lipoprotein (HDL) cholesterol levels and the adiponectin/STA ratio when compared with HFS.ConclusionsOur results suggest that the chronic administration of EGCG (60 days) promoted a significant improvement in glucose tolerance, decreased adipose tissue deposits, weight mass, TG and HDL-C only when associated with high-fat diet treatment.

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Supplementing alpha-tocopherol (vitamin E) and vitamin D3 in high fat diet decrease IL-6 production in murine epididymal adipose tissue and 3T3-L1 adipocytes following LPS stimulation

Cited by 77 publications

References 39 publications

Lipophilic Micronutrients and Adipose Tissue Biology

Lipophilic Micronutrients and Adipose Tissue Biology

Vitamin D and Physical Activity

Metabolic profile response to administration of epigallocatechin-3-gallate in high-fat-fed mice

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